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Review Article|Articles in Press

Multidisciplinary Care in Heart Failure Services

      Highlights

      • Heart failure (HF) guidelines currently recommend a multidisciplinary team approach for patients with HF
      • A structured multidisciplinary HF approach should be incorporated to improve clinical and patient-centered outcomes
      • This guidance should be helpful in implementing the structured multidisciplinary HF approach in the real-world practice

      Abstract

      The American College of Cardiology/American Heart Association /Heart Failure Society of American 2022 guidelines for heart failure (HF) recommend a multidisciplinary team approach for patients with HF. The multidisciplinary HF team-based approach reduces the hospitalization rate for HF and healthcare costs and improves adherence to self-care and utilization of GDMT. This manuscript proposes the optimal multidisciplinary team structure and each team member's delineated role to achieve institutional goals and metrics for HF care. The proposed HF-specific multidisciplinary team comprises cardiologists, surgeons, advanced practice providers, clinical pharmacists, specialty nurses, dieticians, physical therapists, psychologists, social workers, immunologists, and palliative care clinicians. A standardized multidisciplinary HF team-based approach should be incorporated to optimize the structure, minimize redundancy of clinical responsibilities among team members, and improve clinical outcomes and patient satisfaction in their HF care.

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      References

      1. Heart Failure. CDC, 2020. Accessed 11/17/2021, 2021, at https://www.cdc.gov/heartdisease/heart_failure.htm.

        • Heidenreich PA
        • Bozkurt B
        • Aguilar D
        • Allen LA
        • Byun J
        • Colvin MM
        • et al.
        2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.
        Circulation. 2022; 145: e895-e1032
        • Weinstein JM
        • Greenberg D
        • Sharf A
        • Simon-Tuval T.
        The impact of a community-based heart failure multidisciplinary team clinic on healthcare utilization and costs.
        ESC Heart Fail. 2022; 9: 676-684
        • Horne BD
        • Roberts CA
        • Rasmusson KD
        • Buckway J
        • Alharethi R
        • Cruz J
        • et al.
        Risk score-guided multidisciplinary team-based Care for Heart Failure Inpatients is associated with lower 30-day readmission and lower 30-day mortality.
        Am Heart J. 2020; 219: 78-88
        • Holland R
        • Battersby J
        • Harvey I
        • Lenaghan E
        • Smith J
        • Hay L.
        Systematic review of multidisciplinary interventions in heart failure.
        Heart. 2005; 91: 899-906
        • McAlister FA
        • Stewart S
        • Ferrua S
        • McMurray JJ.
        Multidisciplinary strategies for the management of heart failure patients at high risk for admission: a systematic review of randomized trials.
        J Am Coll Cardiol. 2004; 44: 810-819
        • Parajuli DR
        • Kourbelis C
        • Franzon J
        • Newman P
        • Mckinnon RA
        • Shakib S
        • et al.
        Effectiveness of the Pharmacist-Involved Multidisciplinary Management of Heart Failure to Improve Hospitalizations and Mortality Rates in 4630 Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
        J Card Fail. 2019; 25: 744-756
        • Davidson PM
        • Newton PJ
        • Tankumpuan T
        • Paull G
        • Dennison-Himmelfarb C.
        Multidisciplinary management of chronic heart failure: principles and future trends.
        Clin Ther. 2015; 37: 2225-2233
        • Cooper LB
        • Hernandez AF.
        Assessing the Quality and Comparative Effectiveness of Team-Based Care for Heart Failure: Who, What, Where, When, and How.
        Heart Fail Clin. 2015; 11: 499-506
        • Bellam N
        • Kelkar AA
        • Whellan DJ.
        Team-Based Care for Managing Cardiac Comorbidities in Heart Failure.
        Heart Fail Clin. 2015; 11: 407-417
        • Creaser JW
        • DePasquale EC
        • Vandenbogaart E
        • Rourke D
        • Chaker T
        • Fonarow GC.
        Team-Based Care for Outpatients with Heart Failure.
        Heart Fail Clin. 2015; 11: 379-405
        • Larsen PM
        • Teerlink JR.
        Team-based Care for Patients Hospitalized with Heart Failure.
        Heart Fail Clin. 2015; 11: 359-370
        • Morton G
        • Masters J
        • Cowburn PJ.
        Multidisciplinary team approach to heart failure management.
        Heart. 2018; 104: 1376-1382
        • Wever-Pinzon O
        • Drakos SG
        • Fang JC.
        Team-based Care for Advanced Heart Failure.
        Heart Fail Clin. 2015; 11: 467-477
        • Capomolla S
        • Febo O
        • Ceresa M
        • Caporotondi A
        • Guazzotti G
        • Rovere ML
        • et al.
        Cost/utility ratio in chronic heart failure: comparison between heart failure management program delivered by day-hospital and usual care.
        J Am Coll Cardiol. 2002; 40: 1259-1266
        • Maru S
        • Byrnes J
        • Carrington MJ
        • Chan YK
        • Thompson DR
        • Stewart S
        • et al.
        Cost-effectiveness of home versus clinic-based management of chronic heart failure: Extended follow-up of a pragmatic, multicentre randomized trial cohort - The WHICH? study (Which Heart Failure Intervention Is Most Cost-Effective & Consumer Friendly in Reducing Hospital Care).
        Int J Cardiol. 2015; 201: 368-375
        • Hollenberg SM
        • Warner Stevenson L
        • Ahmad T
        • Amin VJ
        • Bozkurt B
        • Bulter J
        • et al.
        2019 ACC Expert Consensus Decision Pathway on Risk Assessment, Management, and Clinical Trajectory of Patients Hospitalized With Heart Failure: A Report of the American College of Cardiology Solution Set Oversight Committee.
        J Am Coll Cardiol. 2019; 74: 1966-2011
        • Case R
        • Haynes D
        • Holaday B
        • Parker VG.
        Evidence-based nursing: the role of the advanced practice registered nurse in the management of heart failure patients in the outpatient setting.
        Dimens Crit Care Nurs. 2010; 29: 57-62
        • Rosano GMC
        • Vitale C
        • Adamo M
        • Metra M.
        Roadmap for the management of heart failure patients during the vulnerable phase after heart failure hospitalizations: how to implement excellence in clinical practice.
        J Cardiovasc Med (Hagerstown). 2022; 23: 149-156
        • Lowery J
        • Hopp F
        • Subramanian U
        • Wiitala W
        • Welsh DE
        • Larkin A
        • et al.
        Evaluation of a nurse practitioner disease management model for chronic heart failure: a multi-site implementation study.
        Congest Heart Fail. 2012; 18: 64-71
        • Albert NM
        • Barnason S
        • Deswal A
        • Hernandez A
        • Kociol R
        • Lee E
        • et al.
        Transitions of care in heart failure: a scientific statement from the.
        American Heart Association. Circ Heart Fail. 2015; 8: 384-409
        • Xu H.
        • Granger B.
        • Drake C.
        • Peterson E.
        • Dupre M.
        Effectiveness of Telemedicine visits in reducing 30-Day Readmissions Among Patients with Heart Failure During the COVID-19 Pandemic.
        J Am Heart Assoc. 2022; 11e023935
        • Wiggins BS
        • Rodgers JE
        • DiDomenico RJ
        • Cook AM
        • Page RL.
        Discharge counseling for patients with heart failure or myocardial infarction: a best practices model developed by members of the American College of Clinical Pharmacy's Cardiology Practice and Research Network based on the Hospital to Home (H2H) Initiative.
        Pharmacotherapy. 2013; 33: 558-580
        • Dunn SP
        • Birtcher KK
        • Beavers CJ
        • Baker WL
        • Brouse SD
        • Page RL
        • et al.
        The role of the clinical pharmacist in the care of patients with cardiovascular disease.
        J Am Coll Cardiol. 2015; 66: 2129-2139
        • Milfred-Laforest SK
        • Chow SL
        • Didomenico RJ
        • Dracup K
        • Ensor CR
        • Gattis-Stough W
        • et al.
        Clinical pharmacy services in heart failure: an opinion paper from the Heart Failure Society of America and American College of Clinical Pharmacy Cardiology Practice and Research Network.
        J Card Fail. 2013; 19: 354-369
        • Vest AR
        • Chan M
        • Deswal A
        • Givertz MM
        • Lekavich C
        • Lennie T
        • et al.
        Nutrition, Obesity, and Cachexia in Patients With Heart Failure: A Consensus Statement from the Heart Failure Society of America Scientific Statements Committee.
        J Card Fail. 2019; 25: 380-400
        • Morishita T
        • Uzui H
        • Sato Y
        • Mitsuke Y
        • Tada H.
        Associations between cachexia and metalloproteinases, haemodynamics and mortality in heart failure.
        Eur J Clin Invest. 2021; 51: e13426
        • Konishi M
        • Kagiyama N
        • Kamiya K
        • Saito H
        • Saito K
        • Ogasahara Y
        • et al.
        Impact of sarcopenia on prognosis in patients with heart failure with reduced and preserved ejection fraction.
        Eur J Prev Cardiol. 2021; 28: 1022-1029
        • Kato TS
        • Kitada S
        • Yang J
        • Wu C
        • Takayama H
        • Naka Y
        • et al.
        Relation of preoperative serum albumin levels to survival in patients undergoing left ventricular assist device implantation.
        Am J Cardiol. 2013; 112: 1484-1488
        • Kuehneman T
        • Gregory M
        • de Waal D
        • Davidson P
        • Frickel R
        • King C
        • et al.
        Academy of Nutrition and Dietetics Evidence-Based Practice Guideline for the Management of Heart Failure in Adults.
        J Acad Nutr Diet. 2018; 118: 2331-2345
        • Kugler C
        • Malehsa D
        • Schrader E
        • Tegtbur U
        • Guetzlaff E
        • Haverich A
        • et al.
        A multi-modal intervention in management of left ventricular assist device outpatients: dietary counselling, controlled exercise and psychosocial support.
        Eur J Cardiothorac Surg. 2012; 42: 1026-1032
        • Shoemaker MJ
        • Dias KJ
        • Lefebvre KM
        • Heick JD
        • Collins SM.
        Physical Therapist Clinical Practice Guideline for the Management of Individuals With Heart Failure.
        Phys Ther. 2020; 100: 14-43
        • Dunlay SM
        • Park SJ
        • Joyce LD
        • Daly R
        • Stulak JM
        • McNallan SM
        • et al.
        Frailty and outcomes after implantation of left ventricular assist device as destination therapy.
        J Heart Lung Transplant. 2014; 33: 359-365
        • Macdonald PS
        • Gorrie N
        • Brennan X
        • Aili SR
        • Silva RD
        • Jha SR
        • et al.
        The impact of frailty on mortality after heart transplantation.
        J Heart Lung Transplant. 2021; 40: 87-94
        • Pandey A
        • Kitzman D
        • Reeves G.
        Frailty Is Intertwined With Heart Failure: Mechanisms, Prevalence, Prognosis, Assessment, and Management.
        JACC Heart Fail. 2019; 7: 1001-1011
        • Bozkurt B
        • Fonarow GC
        • Goldberg LR
        • Guglin M
        • Josephson RA
        • Forman DE
        • et al.
        Cardiac Rehabilitation for Patients With Heart Failure: JACC Expert Panel.
        J Am Coll Cardiol. 2021; 77: 1454-1469
        • Lund LH
        • Edwards LB
        • Kucheryavaya AY
        • Dipchand A
        • Benden C
        • Christie JD
        • et al.
        The Registry of the International Society for Heart and Lung Transplantation: Thirtieth Official Adult Heart Transplant Report–2013; focus theme: age.
        J Heart Lung Transplant. 2013; 32: 951-964
        • Kransdorf EP
        • Kittleson MM
        • Patel JK
        • Pando MJ
        • Steidley DE
        • Kobashigawa JA.
        Calculated panel-reactive antibody predicts outcomes on the heart transplant waiting list.
        J Heart Lung Transplant. 2017; 36: 787-796
        • Costanzo MR
        • Dipchand A
        • Starling R
        • Anderson A
        • Chan M
        • Desai S
        • et al.
        The International Society of Heart and Lung Transplantation Guidelines for the care of heart transplant recipients.
        J Heart Lung Transplant. 2010; 29: 914-956
        • Kobashigawa J
        • Mehra M
        • West L
        • Kerman R
        • George J
        • Rose M
        • et al.
        Report from a consensus conference on the sensitized patient awaiting heart transplantation.
        J Heart Lung Transplant. 2009; 28: 213-225
        • Braun LT
        • Grady KL
        • Kutner JS
        • Adler E
        • Berlinger N
        • Boss R
        • et al.
        Palliative Care and Cardiovascular Disease and Stroke: A Policy Statement From the American Heart Association/American Stroke Association.
        Circulation. 2016; 134: e198-e225
        • Hill L
        • Prager Geller T
        • Baruah R
        • Beattie JM
        • Boyne J
        • de Stoutz N
        • et al.
        Integration of a palliative approach into heart failure care: a European Society of Cardiology Heart Failure Association position paper.
        Eur J Heart Fail. 2020; 22: 2327-2339
        • Farhad S.
        • Prakash A.
        • Noonan G.
        • Maurides S.
        • Anas A.
        • Suhaib B.
        • et al.
        Palliative Inotropes in Advanced Heart Failure: Comparing Outcomes Between Milrinone and Dobutamine.
        J Card Fail. 2022; 28: 1683-1691
        • Kittleson MM
        • Barone H
        • Cole RM
        • Olman M
        • Fishman A
        • Olanisa L
        • et al.
        The Impact of a High-risk Psychosocial Assessment on Outcomes After Durable Mechanical Circulatory Support.
        ASAIO J. 2021; 67: 436-442
        • Clancy MJ
        • Jessop AB
        • Logerstedt D.
        Recommendations for Psychosocial Evaluation of VAD candidates: Adoption, completion, and barriers to implementation.
        Heart Lung. 2021; 51: 52-58
        • Dew MA
        • DiMartini AF
        • Dobbels F
        • Grady KL
        • Jowsey-Gregoire SG
        • Kaan A
        • et al.
        The Approach to the Psychosocial Evaluation of Cardiac Transplant and Mechanical Circulatory Support Candidates.
        Curr Heart Fail Rep. 2019; 16: 201-211
        • Dew MA
        • DiMartini AF
        • Dobbels F
        • Grady KL
        • Jowsey-Gregoire SG
        • Kaan A
        • et al.
        The 2018 ISHLT/APM/AST/ICCAC/STSW Recommendations for the Psychosocial Evaluation of Adult Cardiothoracic Transplant Candidates and Candidates for Long-term Mechanical Circulatory Support.
        Psychosomatics. 2018; 59: 415-440
        • Dew MA
        • Rosenberger EM
        • Myaskovsky L
        • DiMartini AF
        • Devito Dabbs AJ
        • Posluszny DM
        • et al.
        Depression and Anxiety as Risk Factors for Morbidity and Mortality After Organ Transplantation: A Systematic Review and Meta-Analysis.
        Transplantation. 2015; 100: 988-1003
        • Bürker BS
        • Gullestad L
        • Gude E
        • Havik OE
        • Authen AR
        • Grov I
        • et al.
        The Predictive Value of Depression in the Years After Heart Transplantation for Mortality During Long-Term Follow-Up.
        Psychosom Med. 2019; 81: 513-520
        • Vishwanath S
        • Qaderi V
        • Steves CJ
        • Reid CM
        • Hopper I
        • Ryan J.
        Cognitive Decline and Risk of Dementia in Individuals With Heart Failure: A Systematic Review and Meta-analysis.
        J Card Fail. 2021; 28: 1337-1348
        • Cho SM
        • Floden D
        • Wallace K
        • Hiivala N
        • Joseph S
        • Teuteberg J
        • et al.
        Long-Term Neurocognitive Outcome in Patients With Continuous Flow Left Ventricular Assist Device.
        JACC Heart Fail. 2021; 9: 839-851
        • Massaro AR.
        Neurological complications of heart failure.
        Handb Clin Neurol. 2021; 177: 77-89
        • Pavol MA
        • Boehme AK
        • Yuzefpolskaya M
        • Maurer MS
        • Casida J
        • Festa JR
        • et al.
        Cognition predicts days-alive-out-of-hospital after LVAD implantation.
        Int J Artif Organs. 2021; 44: 952-955
        • Pavol MA
        • Boehme AK
        • Willey JZ
        • Festa JR
        • Lazar RM
        • Nakagawa S
        • et al.
        Predicting post-LVAD outcome: Is there a role for cognition?.
        Int J Artif Organs. 2021; 44: 237-242
        • Hassett CE
        • Cho SM
        • Rice CJ
        • Migdady I
        • Starling RC
        • Uchino K
        • et al.
        Cerebral Microembolization in Left Ventricular Assist Device Associated Ischemic Events.
        J Stroke Cerebrovasc Dis. 2020; 29104660
        • Ryu B
        • Ishikawa T
        • Yamaguchi K
        • Matsuoka G
        • Eguchi S
        • Kawamata T.
        Long-term outcomes following thrombectomy for acute ischemic stroke in patients with a left ventricular assist device: a case series and literature review.
        Acta Neurochir (Wien). 2018; 160: 1729-1735
        • Hulde N
        • Koster A
        • von Dossow V.
        Perioperative management of patients with undergoing durable mechanical circulatory support.
        Ann Transl Med. 2020; 8: 830
        • Maurer MS
        • Horn E
        • Reyentovich A
        • Dickson VV
        • Pinney S
        • Goldwater D
        • et al.
        Can a Left Ventricular Assist Device in Individuals with Advanced Systolic Heart Failure Improve or Reverse Frailty?.
        J Am Geriatr Soc. 2017; 65: 2383-2390
        • Casida JM
        • Wu HS
        • Abshire M
        • Ghosh B
        • Yang JJ.
        Cognition and adherence are self-management factors predicting the quality of life of adults living with a left ventricular assist device.
        J Heart Lung Transplant. 2017; 36: 325-330
        • Hu L
        • Lingler JH
        • DeVito Dabbs A
        • Dew MA
        • Sereika SM
        Trajectories of self-care agency and associated factors in lung transplant recipients over the first 12 months following transplantation.
        Clin Transplant. 2017; : 31
        • Casida J
        • Aikens J
        • Pagani F
        • Ewald G
        • Craddock H
        • Pavol M
        • et al.
        Advancing the Science of Self-Management in Adults With Long-Term Left Ventricular Assist Devices.
        Artif Organs. 2018; 42: 1095-1103
        • Levine GN
        • Cohen BE
        • Commodore-Mensah Y
        • Fluery J
        • Huffman JC
        • Khalid U
        • et al.
        Psychological Health, Well-Being, and the Mind-Heart-Body Connection: A Scientific Statement From the American Heart Association.
        Circulation. 2021; 143: e763-e783
        • Duerinckx N
        • Smith PJ
        • Vanhaecke J
        • De Geest S
        • Van Cleemput J
        • Lenaerts S
        • et al.
        Depressive symptoms at 1 year after surgery increase the risk of cardiac allograft vasculopathy and mortality in heart transplant recipients: A prospective cohort study.
        Gen Hosp Psychiatry. 2021; 71: 20-26
        • Fendler TJ
        • Swetz KM
        • Allen LA.
        Team-based Palliative and End-of-life Care for Heart Failure.
        Heart Fail Clin. 2015; 11: 479-498
        • Cagle JG
        • Bunting M
        • Kelemen A
        • Lee J
        • Terry D
        • Harris R.
        Psychosocial needs and interventions for heart failure patients and families receiving palliative care support: a systematic review.
        Heart Fail Rev. 2017; 22: 565-580
        • Simon ST
        • Kini V
        • Levy AE
        • Ho PM.
        Medication adherence in cardiovascular medicine.
        BMJ. 2021; 374: n1493
        • Sanchez GM
        • Douglass MA
        • Mancuso MA.
        Revising project re-engineered discharge (RED): the impact of a pharmacist telephone intervention on hospital readmission rate.
        Pharmacotherapy. 2015; 35: 805-812
        • Heidenreich PA
        • Fonarow GC
        • Breathett K
        • Jurgens CY
        • Pisani BA
        • Pozehl BJ
        • et al.
        2020 ACC/AHA clinical performance and quality measures for adults with heart failure: a report of the American College of Cardiology/American Heart Association Task Force on performance meaures.
        J Am Coll Cardiol. 2020; 76: 2527-2564
      2. National quality forum. Cardiovascular standing committee. Accessed 7/18, 2022 at https://www.qualityforum.org/ProjectMeasures.aspx?projectID=86074&cycleNO=1&cycleYear=2019

        • Bozkurt B
        • Hershberger RE
        • Butler J
        • Grady KL
        • Heidenreich PA
        • Isler ML
        • et al.
        2021 ACC/AHA key data elements and definitions for heart failure: a report of the American College of Cardiology/American Heart Association Task Force on clinical data standards (writing committee to develop clinical data standards for heart failure).
        Circ Cardiovasc Qual Outcomes. 2021; 14e000102
      3. Organ Procurement and Transplantation Network Bylaws. U.S. Department of Health & Human Services, 2021. Accessed 5/7, 2022, at, https://optn.transplant.hrsa.gov/policies-bylaws/bylaws/.

      4. Get with the guidelines® - heart failure overview. American Heart Association. Accessed 8/19, 2022 at https://www.heart.org/en/professional/quality-improvement/get-with-the-guidelines/get-with-the-guidelines-heart-failure/get-with-the-guidelines-heart-failure-overview.

        • Rich MW
        • Beckham V
        • Wittenberg C
        • Leven CL
        • Freedland KE
        • Carney RM.
        A multidisciplinary intervention to prevent the readmission of elderly patients with congestive heart failure.
        N Engl J Med. 1995; 333: 1190-1195
        • Gattis WA
        • Hasselblad V
        • Whellan DJ
        • O'Connor CM
        Reduction in heart failure events by the addition of a clinical pharmacist to the heart failure management team: results of the Pharmacist in Heart Failure Assessment Recommendation and Monitoring (PHARM) Study.
        Ach Intern Med. 1999; 159: 1939-1945
        • Kasper EK
        • Gerstenblith G
        • Hefter G
        • Anden EV
        • Brinker JA
        • Thiemann DR
        • et al.
        A randomized trial of the efficacy of multidisciplinary care in heart failure outpatients at high risk of hospital readmission.
        J Am Coll Cardiol. 2002; 39: 471-480
        • Ducharme A
        • Doyon O
        • White M
        • Rouleau JL
        • Brophy JM.
        Impact of care at a multidisciplinary congestive heart failure clinic: a randomized trial.
        CMAJ. 2005; 173: 40-45
        • Angermann CE
        • Störk S
        • Gelbrich G
        • Faller H
        • Jahns R
        • Frantz S
        • et al.
        Mode of action and effects of standardized collaborative disease management on mortality and morbidity in patients with systolic heart failure: the Interdisciplinary Network for Heart Failure (INH) study.
        Circ Heart Fail. 2012; 5: 25-35
        • Smith CE
        • Piamjariyakul U
        • Wick JA
        • Spertus JA
        • Russell C
        • Dalton KM
        • et al.
        Multidisciplinary group clinic appointments: the Self-Management and Care of Heart Failure (SMAC-HF) trial.
        Circ Heart Fail. 2014; 7: 888-894
        • Mao CT
        • Liu MH
        • Hsu KH
        • Fu TC
        • Wang JS
        • Huang YY
        • et al.
        Effect of multidisciplinary disease management for hospitalized heart failure under a national health insurance programme.
        J Cardiovasc Med (Hagerstown). 2015; 16: 616-624
        • Chen Y
        • Funk M
        • Wen J
        • Tang X
        • He G
        • Liu H.
        Effectiveness of a multidisciplinary disease management program on outcomes in patients with heart failure in China: A randomized controlled single center study.
        Heart Lung. 2018; 47: 24-31
        • Huynh Q
        • Whitmore K
        • Negishi K
        • Marwick T
        ETHELRED investigators. Influence of risk on reduction of readmission and death by disease management programs in heart failure.
        J Card Fail. 2019; 25: 330-339
        • Schulz M
        • Griese-Mammen N
        • Anker SD
        • Koehler F
        • Ihle P
        • Ruckes C
        • et al.
        Pharmacy-based interdisciplinary intervention for patients with chronic heart failure: results of the PHARM-CHF randomized controlled trial.
        Eur J Heart Fail. 2019; 21: 1012-1021