Pulmonary hypertension (PH) is a disease diagnosed with a mean pulmonary arterial
pressure (mPAP) > 20 mmHg [
[1]
]. Early screening for PH is crucial because, if this disease is left untreated, the
disease progresses to heart failure and premature death, with a median survival period
of two to three years [
[1]
]. The current standard method for PH diagnosis is the right heart catheterization
(RHC), but this procedure is invasive and is associated with risks such as bleeding
or cardiac arrhythmias [
[1]
]. Other methods used for screening for PH such as echocardiograms are only routinely
used in patients with a high prevalence of PH, such as those with systemic sclerosis
[
[2]
]. However, current approaches are resource intensive and are restricted to patients
with a high prevalence of PH. Until recently a population-based approach for screening
for PH was not available.Acronyms
- 95% CI, 95th percentile confidence interval
- AI, artificial intelligence
- AUC, area under the receiver operating characteristic curve
- ECG, electrocardiogram
- ICD, International Classification of Disease
- mPAP, mean pulmonary arterial pressure
- NPV, negative predictive value
- PH, pulmonary hypertension
- PPV, positive predictive value
- RHC, right heart catheterization
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Biography
Robert AvramBiography
Elodie Labrecque LanglaisArticle info
Publication history
Accepted:
February 8,
2023
Received:
February 7,
2023
Publication stage
In Press Journal Pre-ProofIdentification
Copyright
© 2023 Elsevier Inc. All rights reserved.
