- •Modified HIIT is safe in patients with LVADs.
- •Short bouts of HIIT are feasible and improve VO2 peak and functional parameters.
High-intensity interval training (HIIT) of 4 minutes at 80%–90% of peak oxygen consumption (VO2peak) has been shown to be feasible in patients with left ventricular assist devices (LVADs). The effect of shorter bouts of HIIT, which reduce the anaerobic burden, has not been investigated compared to moderate continuous training (MCT).
Methods and Results
We conducted a prospective, monocentric study (NCT05121077) randomizing patients with LVADs into 20 minutes of MCT (n = 10) or short bouts (≤ 90 seconds) of HIIT (n = 10) following cardiopulmonary exercise testing at 50%–60% and 80%–90% of VO2peak. Each of the 18 supervised sessions (3×/week, t0–t1) included 10 minutes of strengthening training. The primary outcome was the increase of VO2peak in the 2 groups between t0 and t1. Secondary outcomes were changes in the 12-item Kansas City Cardiomyopathy Questionnaire, the 6-minute walk distance and the percentage of VO2peak at the first ventilatory threshold. VO2peak significantly increased with HIIT (13.0 ± 4.6mL/kg/min vs 14.6 ± 4.3mL/kg/min; P = 0.037), but not with MCT (11.8 ± 3.3mL/kg/min vs 13.1 ± 3.3mL/kg/min; P = 0.322), without between-group differences (P = 0.853). Secondary outcomes improved from t0–t1 in MCT and HIIT, without differences between the groups.
Short bouts of HIIT are feasible, and they improved VO2peak and functional parameters in patients in this pilot prospective study.
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- Changes in cardiopulmonary exercise testing parameters following continuous flow left ventricular assist device implantation and heart transplantation.J Card Fail. 2014; 20: 548-554
- Cardiac rehabilitation improves functional capacity and patient-reported health status in patients with continuous-flow left ventricular assist devices: the Rehab-VAD randomized controlled trial.JACC Heart Fail. 2014; 2: 653-659
- High-intensity interval training in patients with heart failure with reduced ejection fraction.Circulation. 2017; 135: 839-849
- 2016 focused update: clinical recommendations for cardiopulmonary exercise testing data assessment in specific patient populations.Eur Heart J. 2018; 39: 1144-1161
- R: a language and environment for statistical computing.R Foundation for Statistical Computing, Vienna, Austria,2021(Accessed Sept. 25, 2022)
- High-intensity interval training in patients with left ventricular assist devices: a pilot randomized controlled trial.J Heart Lung Transplant. 2020; 39: 1380-1388
- Superior cardiovascular effect of aerobic interval training versus moderate continuous training in heart failure patients: a randomized study.Circulation. 2007; 115: 3086-3094
- Feasibility of high-intensity interval training in patients with left ventricular assist devices: a pilot study.ESC Heart Fail. 2021; 8: 498-507
Published online: February 07, 2023
Accepted: January 26, 2023
Received in revised form: January 19, 2023
Received: December 19, 2022
Publication stageIn Press Journal Pre-Proof
#HIIT in LVAD: High-intensity interval training is both safe and beneficial in patients with LVADs.
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