Three bullet points
- •Heart failure is a very prevalent condition in people over 65 years old and therefore, it is important to investigate the factors that are involved in increasing both morbidity and mortality.
- •In the era of vaccination in which we find ourselves, it is important to continuously try to show the protective effect of this medical tool. In this case, not only in patients with chronic heart failure, also in those with acute heart failure.
- •Spending time researching which methods can protect our patients that suffer from heart failure, makes us having more possibilities to improve their life expectancy and quality.
Abstract
Graphical Abstract

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- ADHERE Scientific Advisory Committee. Overview of acutely decompensated congestive heart failure (ADHF): a report from the ADHERE registry.Heart Fail Rev. 2004; 9: 179-185
- Time trends in characteristics, clinical course, and outcomes of 13,791 patients with acute heart failure.Clin Res Cardiol. 2018; 107: 897-913
- Management of acute decompensated heart failure in Spain: Where are we now?.Emergencias. 2022; 34: 81-82
- Thirty-day outcomes in frail older patients discharged home from the emergency department with acute heart failure: effects of high-risk criteria identified by the DEED FRAIL-AHF trial.Emergencias. 2021; 33: 165-173
- ESC Heart Failure Long-Term Registry Investigators. Clinical phenotypes and outcome of patients hospitalized for acute heart failure: the ESC Heart Failure Long-Term Registry.Eur J Heart Fail. 2017; 19: 1242-1254
- Trends and complications associated with acute new-onset heart failure: a National Readmissions Database-based cohort study.Heart Fail Rev. 2021; (in press)https://doi.org/10.1007/s10741-021-10152-3
- In-hospital initiation of quadruple medical therapy for heart failure: making the post-discharge vulnerable phase far less vulnerable.Eur J Heart Fail. 2022; 24: 227-229
- Factors associated with in-hospital mortality and adverse outcomes during the vulnerable post-discharge phase after the first episode of acute heart failure: results of the NOVICA-2 study.Clin Res Cardiol. 2021; 110: 993-1005
- Influenza Vaccination and Outcome in Heart Failure.Am J Cardiol. 2020; 128: 134-139
- Estimates of global seasonal influenza-associated respiratory mortality: a modelling study.Lancet. 2018; 391: 1285-1300
- Global burden of influenza-associated lower respiratory tract infections and hospitalizations among adults: A systematic review and meta-analysis.PLoS Med. 2021; 18e1003550
- Impact of identifying precipitating factors on 30-day mortality in acute heart failure patients.Eur Heart J Acute Cardiovasc Care. 2019; 8: 667-680
- Current Spanish emergency department organization and clinical practices in caring for patients with acute heart failure.Emergencias. 2022; 34: 85-94
- Prevalence and prognostic importance of precipitating factors leading to heart failure hospitalization: recurrent hospitaliza- tions and mortality.Eur J Heart Fail. 2018; 20: 295-303
- Burden, effectiveness and safety of influenza vaccines in elderly, paediatric and pregnant populations.Ther Adv Vaccines Immunother. 2019 Feb 7; 72515135519826481
- 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure.Eur Heart J. 2021; 42: 3599-3726
- 2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines.Circulation. 2013; 128: 1810-1852
- Sarría-Santamera A. Effects of annual influenza vaccination on mortality in patients with heart failure.Eur J Public Health. 2016; 26: 890-892
- Safety and the identification of modifiable factors in older patients discharged from the emergency department with acute heart failure.Emergencias. 2021; 33: 161-162
- Influenza vaccination in patients with chronic heart failure: The PARADIGM-HF Trial.JACC Heart Fail. 2016; 4: 152-158
- Influenza vaccination and risk of hospitalization in patients with heart failure: a self-con- trolled case series study.Eur Heart J. 2017; 38: 326-333
- Predicting 30-Day Mortality for Patients With Acute Heart Failure in the Emergency Department: A Cohort Study.Ann Intern Med. 2017; 167: 698-705
- Acute heart failure in subtropical climates: clinical characteristics, management, and outcomes in the Canary Islands versus continental Spain -the CANAR-ICA study results.Emergencias. 2021; 33: 413-420
- Survival after the onset of congestive heart failure in Framingham heart study subjects.Circulation. 1993; 88: 107-115
- Long-term survival and life expectancy following an acute heart failure hospitalization.Eur J Heart Fail. 2022; 24: 1519-1528
Miró O, Conde-Martel A, Llorens P, Salamanca-Bautista P, Gil V, González-Franco A, et al. The influence of comorbiditeis in long-term prognosis after an acute heart failure decompensation and differences according to ejection fraction: results from the EAHFE and RICA registries. Eur J Intern Med (submitted)
- Principles of confounder selection.Eur J Epidemiol. 2019; 34: 211-219
- The hazards of hazard ratios.Epidemiology. 2010; 21: 13-15
- Precipitating factors and 90-day outcome of acute heart failure: a report from the intercontinental GREAT registry.Eur J Heart Fail. 2017; 19: 201-208
- Time-pattern of adverse outcomes after an infection-triggered acute heart failure decompensation and the influence of early antibiotic administration and hospitalisation: results of the PAPRICA-3 study.Clin Res Cardiol. 2020; 109: 34-45
- Biering-Sørensen T. Influenza Vaccine in Heart Failure.Circulation. 2019; 139: 575-586
- The effect of influenza vaccination on mortality and hospitalization in patients with heart failure: a systematic review and meta-analysis.Heart Fail Rev. 2019; 24: 109-114
- Influenza vaccination in patients with heart failure: a systematic review and meta-analysis of observational studies.Heart. 2020; 106: 350-357
- The impact of ageing on monocytes and macrophages.Immunol Lett. 2021; 230: 1-10
- Influenza vaccination in patients with chronic heart failure: The PARADIGM-HF Trial.JACC Heart Fail. 2016; 4: 152-158
- Safety and the identification of modifiable factors in older patients discharged from the emergency department with acute heart failure[CE: Duplicate referece with refence 19. Please check].Emergencias. 2021; 33: 161-162
- Thirty-day outcomes in frail older patients discharged home from the emergency department with acute heart failure: effects of high-risk criteria identified by the DEED FRAIL-AHF trial[CE: Duplicate referece with refence 4. Please check].Emergencias. 2021; 33: 165-173
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bMembers of the EAHFE research group: Marta Fuentes, Cristina Gil (Hospital Universitario de Salamanca), Héctor Alonso, Enrique Pérez-Llantada (Hospital Marqués de Valdecilla de Santander), Francisco Javier Martín-Sánchez, Guillermo Llopis García, Mar Suárez Cadenas (Hospital Clínico San Carlos de Madrid), Òscar Miró, Víctor Gil, Rosa Escoda, Sira Aguiló, Carolina Sánchez (Hospital Clínic de Barcelona), Javier Millán (Hospital Politénic La Fe de Valencia), José Pavón (Hospital Dr. Negrín de Las Palmas de Gran Canaria), Antonio Noval (Hospital Insular de Las Palmas de Gran Canaria), María Luisa López-Grima, Amparo Valero, María Ángeles Juan (Hospital Dr. Peset de Valencia), Alfons Aguirre, Maria Angels Pedragosa, Silvia Mínguez Masó (Hospital del Mar de Barcelona), María Isabel Alonso, Francisco Ruiz (Hospital de Valme de Sevilla), José Miguel Franco (Hospital Miguel Servet de Zaragoza), Ana Belén Mecina (Hospital de Alcorcón de Madrid), Josep Tost, Marta Berenguer, Ruxandra Donea (Consorci Sanitari de Terrassa), Susana Sánchez Ramón, Virginia Carbajosa Rodríguez (Hospital Universitario Rio Hortega de Valladolid), Pascual Piñera, José Andrés Sánchez Nicolás (Hospital Reina Sofía de Murcia), Raquel Torres Garate (Hospital Severo Ochoa de Madrid), Aitor Alquézar-Arbé, Miguel Alberto Rizzi, Sergio Herrera (Hospital de la Santa Creu y Sant Pau de Barcelona), Javier Jacob, Alex Roset, Irene Cabello, Antonio Haro (Hospital Universitari de Bellvitge de Barcelona), Fernando Richard, José María Álvarez Pérez, María Pilar López Diez (Hospital Universitario de Burgos), Pablo Herrero Puente, Joaquín Vázquez Álvarez, Belén Prieto García, María García García, Marta Sánchez González (Hospital Universitario Central de Asturias de Oviedo), Pere Llorens, Patricia Javaloyes, Inmaculada Jiménez, Néstor Hernández, Begoña Espinosa, Adriana Gil, Francisca Molina, Tamara García (Hospital General de Alicante), Juan Antonio Andueza (Hospital General Universitario Gregorio Marañón de Madrid), Rodolfo Romero (Hospital Universitario de Getafe de Madrid), Martín Ruíz, Roberto Calvache (Hospital de Henares de Madrid), María Teresa Lorca Serralta, Luis Ernesto Calderón Jave (Hospital del Tajo de Madrid), Beatriz Amores Arriaga, Beatriz Sierra Bergua (Hospital Clínico Lozano Blesa de Zaragoza), Enrique Martín Mojarro, Brigitte Silvana Alarcón Jiménez (Hospital Sant Pau i Santa Tecla de Tarragona), Lisette Travería Bécquer, Guillermo Burillo (Hospital Universitario de Canarias de Tenerife), Lluís Llauger García, Gerard Corominas LaSalle. (Hospital Universitari de Vic de Barcelona), Carmen Agüera Urbano, Ana Belén García Soto, Elisa Delgado Padial (Hospital Costa del Sol de Marbella de Málaga), Ester Soy Ferrer, María Adroher Múñoz (Hospital Josep Trueta de Girona). José Manuel Garrido (Hospital Virgen Macarena de Sevilla), Francisco Javier Lucas-Imbernón (Hospital General Universitario de Albacete), Rut Gaya (Hospital Juan XXIII de Tarragona), Carlos Bibiano, María Mir, Beatriz Rodríguez (Hospital Infanta Leonor de Madrid), José Luis Carballo (Complejo Hospitalario Universitario de Ourense), Esther Rodríguez-Adrada, Belén Rodríguez Miranda, Monika Vicente Martín (Hospital Rey Juan Carlos de Móstoles de Madrid). Pere Coma Casanova, Joan Espinach Alvarós (Hospital San Joan de Deu de Martorell, Barcelona).
Lay summary
Heart failure is nowadays a chronic condition suffered by many people over 65 years old. This makes us look for the factors than can improve the live from those suffering from this affection. Something simple as a flu vaccination, has showed to reduce the mortality. In our study we show that it also reduces the mortality in those who suffer from an acute heart failure. This improves the treatment and the life expectancy.