Research Article| Volume 27, ISSUE 11, P1291-1294, November 2021

Download started.


Left Ventricular Assist Devices at the Crossroad of Innovation in Advanced Heart Failure

      Key Words

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Journal of Cardiac Failure
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Stewart GC
        • Mehra MR.
        A history of devices as an alternative to heart transplantation.
        Heart Fail Clin. 2014; 10: S1-12
        • Sidhu K
        • Lam PH
        • Mehra MR.
        Evolving trends in mechanical circulatory support: clinical development of a fully magnetically levitated durable ventricular assist device.
        Trends Cardiovasc Med. 2020; 30: 223-229
        • Pinney SP
        • Anyanwu AC
        • Lala A
        • Teuteberg JJ
        • Uriel N
        • Mehra MR.
        Left ventricular assist devices for lifelong support.
        J Am Coll Cardiol. 2017; 69: 2845-2861
        • Clegg AJ
        • Scott DA
        • Loveman E
        • Colquitt J
        • Hutchinson J
        • Royle P
        • Bryant J.
        The clinical and cost-effectiveness of left ventricular assist devices for end-stage heart failure: a systematic review and economic evaluation.
        Health Technol Assess. 2005; 9 (iii–iv): 1-132
        • Mehra MR.
        The burden of haemocompatibility with left ventricular assist systems: a complex weave.
        Eur Heart J. 2019; 40: 673-677
        • Mehra MR
        • Stewart GC
        • Uber PA.
        The vexing problem of thrombosis in long-term mechanical circulatory support.
        J Heart Lung Transplant. 2014; 33: 1-11
        • Teuteberg JJ
        • Slaughter MS
        • Rogers JG
        • ADVANCE Trial Investigators
        The HVAD left ventricular assist device: risk factors for neurological events and risk mitigation strategies.
        JACC Heart Fail. 2015; 3: 818-828
        • Milano CA
        • Rogers JG
        • Tatooles AJ
        • ENDURANCE Investigators
        HVAD: The ENDURANCE Supplemental Trial.
        JACC Heart Fail. 2018; 6: 792-802
        • Mehra MR
        • Naka Y
        • Uriel N
        • MOMENTUM 3 Investigators
        A fully magnetically levitated circulatory pump for advanced heart failure.
        N Engl J Med. 2017; 376 (2): 440-450
        • Mehra MR
        • Uriel N
        • Naka Y
        • MOMENTUM 3 Investigators
        A fully magnetically levitated left ventricular assist device - final report.
        N Engl J Med. 2019; 380: 1618-1627
      1. Medtronic. Medtronic to stop distribution and sale of HVADTM system. Available at: Accessed June 8, 2021.

        • Mehra MR.
        Evolving disruption in left ventricular assist systems: forgiving but not yet forgettable.
        Eur J Heart Fail. 2019; 21: 98-100
        • Mehra MR
        • Cleveland Jr, JC
        • Uriel N
        • on behalf of the MOMENTUM 3 Investigators
        Primary results of long-term outcomes in the MOMENTUM 3 pivotal trial and continued access protocol study phase: a study of 2200 HeartMate 3 left ventricular assist device implants.
        Eur J Heart Fail. 2021 May 1;
        • Pagani FD
        • Mehra MR
        • Cowger JA
        • et al.
        Clinical outcomes and healthcare expenditures in the real world with left ventricular assist devices - the CLEAR-LVAD study.
        J Heart Lung Transplant. 2021; 40: 323-333
        • Pagani FD
        • Cantor R
        • Cowger J
        • et al.
        Concordance of treatment effect: an analysis of the Society of Thoracic Surgeons INTERMACS database.
        Ann Thorac Surg. 2021 Jun 1; (S0003-4975(21)00929-2)
        • Baumwol J.
        "I need help—a mnemonic to aid timely referral in advanced heart failure.
        J Heart Lung Transplant. 2017; 36: 593-594
        • Gustafsson F
        • Rogers JG.
        Left ventricular assist device therapy in advanced heart failure: patient selection and outcomes.
        Eur J Heart Fail. 2017; 19: 595-602
        • Mehra MR
        • Costanzo MR.
        Transcatheter mitral valve intervention in advanced heart failure.
        J Heart Lung Transplant. 2020; 39: 1363-1365
        • Hanke JS
        • Rojas SV
        • Dogan G
        • et al.
        First series of left ventricular assist device exchanges to HeartMate 3.
        Eur J Cardiothorac Surg. 2017; 51: 887-892
        • Schmid Daners M
        • Kaufmann F
        • Amacher R
        • et al.
        Left ventricular assist devices: challenges toward sustaining long-term patient care.
        Ann Biomed Eng. 2017; 45: 1836-1851