Abstract
Background
Data regarding a direct comparison of soluble suppression of tumorigenesis-2 (sST2),
pentraxin 3 (PTX3), galectin-3 (Gal-3), and high-sensitivity troponin T of cardiovascular
outcome in patients with heart failure (HF) are lacking.
Methods and Results
A total of 616 hospitalized patients with HF were evaluated prospectively. Biomarker
data were obtained in the stable predischarge condition. sST2 levels were associated
with age, sex, body mass index, inferior vena cava diameter, B-type natriuretic peptide
(BNP), PTX3, C-reactive protein, and Gal-3 levels. During follow-up, 174 (28.4%) primary
composite end points occurred, including 58 cardiovascular deaths and 116 HF rehospitalizations.
sST2 predicted the end point after adjustment for 13 clinical variables (hazard ratio
1.422; 95% confidence interval [CI] 1.064 to 1.895, P = .018). The association between sST2 and the end point was no longer statistically
significant after adjustment for BNP (P = .227), except in the subgroup of patients with preserved ejection fraction (hazard
ratio 1.925, 95% CI 1.102–3.378, P = .021). Gal-3 and high-sensitivity troponin T predicted the risk for the end point
after adjustment for age and sex, but were not significant after adjustment for clinical
variables. The prognostic value of PTX3 was not observed (age and sex adjusted, P = .066).
Conclusions
This study did not show significant additional value of biomarkers to BNP for risk
stratification, except sST2 in patients with preserved ejection fraction.
Key Words
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Article info
Publication history
Published online: June 12, 2021
Accepted:
May 18,
2021
Received in revised form:
April 21,
2021
Received:
February 1,
2021
Identification
Copyright
© 2021 Elsevier Inc. All rights reserved.
