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Research Letter| Volume 27, ISSUE 11, P1295-1297, November 2021

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Higher Requirements of Loop Diuretics in Heart Failure With Chronic Kidney Disease Regardless of Degree of Left Ventricular Dysfunction: From the HF-ACTION trial

  • Author Footnotes
    # There are no conflicts of interest.
    Hesham R. Omar
    Footnotes
    # There are no conflicts of interest.
    Affiliations
    Division of Internal Medicine at Swedish American Hospital, Rockford, Illinois
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  • Author Footnotes
    # There are no conflicts of interest.
    Maya Guglin
    Correspondence
    Reprint requests: Maya Guglin, M.D, Indiana University School of Medicine, Krannert Institute of Cardiology, 1801 Senate Boulevard, Suite 2000, Indianapolis, IN 46202. Tel: (317) 962 0500; Fax: (317) 962 0501.
    Footnotes
    # There are no conflicts of interest.
    Affiliations
    Division of Cardiovascular Medicine, Indiana University, Indianapolis Indiana
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  • Author Footnotes
    # There are no conflicts of interest.
      Decompensated heart failure (HF) is associated with decline in renal function due partially to renal congestion,
      • Guglin M
      • Rivero A
      • Matar F
      • Garcia M
      Renal dysfunction in heart failure is due to congestion but not low output.
      and optimal volume control by means of diuresis can prevent this. Also, chronic kidney disease (CKD) is an independent risk factor for cardiovascular disease. The prevalence of congestive heart failure (HF) increases as a patient's renal function deteriorates. In the Atherosclerosis Risk in Communities (ARIC) study, the incidence of HF was 3-fold higher if the estimated glomerular filtration rate (eGFR) was <60 mL/min/1.73 m2 compared with the reference group that had an eGFR ≥90 mL/min/1.73 m2;
      • Kottgen A
      • Russell SD
      • Loehr LR
      • Crainiceanu CM
      • Rosamond WD
      • Chang PP
      • et al.
      Reduced kidney function as a risk factor for incident heart failure: the Atherosclerosis Risk in Communities (ARIC) study.
      hence, it is expected that a patient with worse kidney functions would have higher diuretic requirements due to associated worse left ventricular function.
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