Background: Dyslipidemia is a well-known risk factor of cardiovascular disease. In the setting of secondary prevention of cardiovascular disease, however, the impact of dyslipidemia on prediction of developing heart failure is not completely understood. Methods and Results: We studied 399 consecutive patients with acute coronary syndrome. Three quarters of the patients had dyslipidemia, which encompassed high low-density lipoprotein cholesterol (LDL-C ≧ 140 mg/dl; 30.2%), low high-density lipoprotein (HDL-C < 40 mg/dl; 26.8%), or high triglycerides (TG ≧ 150 mg/dl; 34.1%). Among the common lipid parameters, low HDL-C has the strongest relation with risk of developing heart failure. Meanwhile, high LDL-C and high TG had no relationship with the risk. Conclusions: Low HDL-C is a robust risk factor of developing heart failure in the setting of post-acute coronary syndrome.
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