Abstract
Objective
For chronic heart failure (CHF), more emphasis has been placed on evaluation of systolic
as opposed to diastolic function. Within the study of diastology, measurements of
left ventricular (LV) longitudinal myocardial relaxation have the most validation.
Anterior wall radial myocardial tissue relaxation velocities along with mitral valve
inflow (MVI) patterns are applicable diastolic parameters in the differentiation between
moderate and severe disease in the ischemic rat model of CHF. Myocardial tissue relaxation
velocities correlate with traditional measurements of diastolic function (ie, hemodynamics,
Tau, and diastolic pressure-volume relationships).
Methods and Results
Male Sprague-Dawley rats underwent left coronary artery ligation or sham operation.
Echocardiography was performed at 3 and 6 weeks after coronary ligation to evaluate
LV ejection fraction (EF) and LV diastolic function through MVI patterns (E, A, and
E/A) and Doppler imaging of the anterior wall (e′ and a′). The rats were categorized
into moderate or severe CHF according to their LV EF at 3 weeks postligation. Invasive
hemodynamic measurements with solid-state pressure catheters were obtained at the
6-week endpoint. Moderate (N = 20) and severe CHF (N = 22) rats had significantly
(P < .05) different EFs, hemodynamics, and diastolic pressure-volume relationships.
Early diastolic anterior wall radial relaxation velocities as well as E/e′ ratios
separated moderate from severe CHF and both diastolic parameters had strong correlations
with invasive hemodynamic measurements of diastolic function.
Conclusion
Radial anterior wall e′ and E/e′ can be used for serial assessment of diastolic function
in rats with moderate and severe CHF.
Key Words
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References
- Heart disease and stroke statistics-2012 update: a report from the American Heart Association.Circulation. 2012; 125: e2-220
- Diastolic function is associated with quality of life and exercise capacity in stable heart failure patients with reduced ejection fraction.Braz J Med Biol Res. 2013; 46: 803-808
- Usefulness of Doppler echocardiographic left ventricular diastolic function and peak exercise oxygen consumption to predict cardiovascular outcomes in patients with systolic heart failure (from HF-ACTION).Am J Cardiol. 2012; 110: 862-869
- Prognostic significance of diastolic dysfunction by tissue Doppler imaging in patients with chronic heart failure.Am J Med Sci. 2009; 337: 415-420
- Mitral flow velocity changes after 6 months of optimized therapy provide important hemodynamic and prognostic information in patients with chronic heart failure.Am Heart J. 1996; 132: 809-819
- Diastolic failure: pathophysiology and therapeutic implications.J Am Coll Cardiol. 1993; 22: 318-325
- Recommendations for the evaluation of left ventricular diastolic function by echocardiography.J Am Soc Echocardiogr. 2009; 22: 107-133
- Time constants of cardiac function and their calculations.Open Cardiovasc Med J. 2010; 4: 168-172
- Recommendations for the evaluation of left ventricular diastolic function by echocardiography.Eur J Echocardiogr. 2009; 10: 165-193
- Implantation of a three-dimensional fibroblast matrix improves left ventricular function and blood flow after acute myocardial infarction.Cell Transplant. 2009; 18: 283-295
- Doppler assessment of left ventricular diastolic function: the refinements continue.J Am Coll Cardiol. 1993; 21: 1697-1700
- “Diastology”: beyond E and A.J Am Coll Cardiol. 1996; 27: 372-374
- Left ventricular fibre architecture in man.Br Heart J. 1981; 45: 248-263
- Relationship of echocardiographic indices to pulmonary capillary wedge pressures in healthy volunteers.J Am Coll Cardiol. 2000; 36: 1664-1669
- Doppler-derived mitral deceleration time of early filling as a strong predictor of pulmonary capillary wedge pressure in postinfarction patients with left ventricular systolic dysfunction.J Am Coll Cardiol. 1994; 23: 1630-1637
- Estimation of left ventricular end-diastolic pressure from Doppler transmitral flow velocity in cardiac patients independent of systolic performance.J Am Coll Cardiol. 1992; 20: 112-119
- Noninvasive evaluation of hemodynamics by Doppler echocardiography.Curr Opin Cardiol. 1999; 14: 217-224
- Feasibility and accuracy of Doppler echocardiographic estimation of pulmonary artery occlusive pressure in the intensive care unit.Am J Cardiol. 1995; 75: 1256-1262
- Doppler tissue imaging: a noninvasive technique for evaluation of left ventricular relaxation and estimation offilling pressures.J Am Coll Cardiol. 1997; 30: 1527-1533
- Doppler echocardiography reliably predicts pulmonary artery wedge pressure in patients with chronic heart failure with and without mitral regurgitation.J Am Coll Cardiol. 1996; 27: 883-893
- Noninvasive estimation of pulmonary arterial wedge pressure with Doppler transmitral flow velocity pattern in patients with known heart disease.Am J Cardiol. 1995; 75: 383-389
- Small and large animal models in cardiac contraction research: advantages and disadvantages.Pharmacol Ther. 2014; 141: 235-249
- Viable fibroblast matrix patch induces angiogenesis and increases myocardial blood flow in heart failure after myocardial infarction.Tissue Eng Part A. 2010; 16: 3065-3073
- An electrically coupled tissue-engineered cardiomyocyte scaffold improves cardiac function in rats with chronic heart failure.J Heart Lung Transplant. 2014; 33: 438-445
- Doppler echocardiographic measurement of low velocity motion of the left ventricular posterior wall.Am J Cardiol. 1989; 64: 66-75
- Colour Doppler velocity imaging of the myocardium.Ultrasound Med Biol. 1992; 18: 651-654
- Roelandt R.F.T. Sutherland G. Iliceto S. Linker D.R. Regional left ventricular wall motion. Churchill Livingtone, UK1993: 241-251
- Independent and incremental prognostic value of Doppler-derived mitral deceleration time of early filling in both symptomatic and asymptomatic patients with left ventricular dysfunction.J Am Coll Cardiol. 1996; 28: 383-390
- Prognostic value of Doppler echocardiographic mitral inflow patterns: implications for risk stratification in patients with congestive heart failure.J Am Coll Cardiol. 2001; 37: 1049-1055
- Restrictive left ventricular filling pattern in dilated cardiomyopathy assessed by Doppler echocardiography: clinical, echocardiographic and hemodynamic correlations and prognostic implications.J Am Coll Cardiol. 1993; 22: 808-815
- Isovolumic relaxation time varies predictably with its time constant and aortic and left atrial pressure: implications for the noninvasive evaluation of ventricular relaxation.Am Heart J. 1992; 124: 1305-1313
- Usefulness of tissue Doppler and color M-mode indexes of left ventricular diastolic function in predicting outcomes in systolic left ventricular heart failure (from the ADEPT study).Am J Cardiol. 2005; 96: 257-262
- Regional diastolic function by pulsed Doppler myocardial mapping for the detection of left ventricular ischemia during pharmacologic stress testing: a comparison with stress echocardiography and perfusion scintigraphy.J Am Coll Cardiol. 2000; 36: 444-452
- Prognostic value of Doppler transmitral flow patterns in patients with congestive heart failure.J Am Coll Cardiol. 1994; 24: 132-139
- Color Doppler myocardial imaging: a new technique for the assessment of myocardial function.J Am Soc Echocardiogr. 1994; 7: 441-458
- Regional diastolic function in ischaemic heart disease using pulsed wave Doppler tissue imaging.Eur Heart J. 1999; 20: 496-505
- Regional diastolic function is more preserved in viable than non-viable myocardium. Demonstration by pulsed-wave Doppler tissue imaging in basal conditions.Rev Esp Cardiol. 2001; 54: 592-596
- Left ventricular filling in dilated cardiomyopathy: relation to functional class and hemodynamics.J Am Coll Cardiol. 1990; 15: 1288-1295
- Fiber orientation in the canine left ventricle during diastole and systole.Circ Res. 1969; 24: 339-347
- Structural basis for cardiac function.Am J Physiol. 1970; 218: 1517-1523
- Clinical utility of Doppler echocardiography and tissue Doppler imaging in the estimation of left ventricular filling pressures: a comparative simultaneous Doppler-catheterization study.Circulation. 2000; 102: 1788-1794
- Doppler Myocardial Imaging: A Textbook.1st ed. BSWK BVBA, Hasselt, Belgium2006
- Survival after an experimental myocardial infarction: beneficial effects of long-term therapy with captopril.Circulation. 1985; 72: 406-412
- Importance of venodilatation in prevention of left ventricular dilatation after chronic large myocardial infarction in rats: a comparison of captopril and hydralazine.Circ Res. 1989; 64: 330-337
- Survival after myocardial infarction in rats: captopril versus losartan.J Am Coll Cardiol. 1996; 27: 714-719
Article info
Publication history
Published online: August 08, 2017
Accepted:
August 1,
2017
Received in revised form:
July 20,
2017
Received:
February 6,
2017
Footnotes
Funding: This work was supported by the WARMER Foundation; the Department of Veterans Affairs; The William and Dorothy Shaftner Memorial Award & the Margarito Chavez Student Award Sarver Heart Center; The Martin and Carol Reid Family Charitable Remainder Trust; and the Hansjörg Wyss Foundation.
Identification
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