Severe heart failure patients with reduced left ventricular ejection fraction (LVEF) still have poor outcomes. The outcome of amiodarone treatment for severe ischemic HF patients is still unknown. We studied 65 patients (67 ± 12 years old, 54 men) with severe HF (New York Heart Association [NYHA] functional class 3 or 4) due to ischemic heart disease treated by amiodarone. During 24 months of follow-up, 44 patients (81%) were died (Fig. 1). 89% of patients were treated with beta-blockers and/or angiotensin-converting-enzyme inhibitors or angiotensin-receptor blockers. After amiodarone treatment, NYHA functional class was significantly improved, and heart rate was significantly decreased than before (Table 1). However, LVEF was not improved. Alternative treatment for severe heart failure patients is needed.
Table 1Changes Before and During Aniodarone Treatment
To read this article in full you will need to make a payment
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:Subscribe to Journal of Cardiac Failure
Already a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect