Background: The mechanism of anemia in cardio-renal anemia syndrome remains completely unknown.
We have previously reported that impaired intestinal iron transporters may contribute
to the mechanism of anemia in heart failure (HF) using HF model rats. In this study,
we assessed intestinal iron transporters in chronic kidney disease (CKD) model rats
to investigate the association of intestinal iron transporters in the mechanism of
cardio-renal anemia syndrome. Methods and Results: CKD was induced by 5/6 nephrectomy in Sprague-Dawley rats. Sham-operated rats served
as a control. After 24 weeks surgery, CKD rats exhibited normocytic normochromic anemia
and normal serum erythropoietin levels despite of anemia. Serum iron levels were decreased
in CKD rats compared with the controls. Of interest, intestinal expression of critical
iron importers such as duodenal cytochrome b and divalent metal transporter 1 was
decreased in CKD rats compared with the controls. On the other hand, intestinal expression
of ferroportin, an intestinal iron exporter, was not different in the control and
CKD groups. Moreover, hepatic expression of hepcidin, a regulator of iron homeostasis,
did not differ between the control and CKD groups. Conclusion: Impaired intestinal iron transporters may be associated with the mechanism of anemia
in cardio-renal anemia syndrome.
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