Background: The relationship renal function and exercise performance has been unclear yet. We estimated the effects of renal function on exercise performance by using the parameters of cardiopulmonary exercise testing (CPX). Methods: Consecutive 110 patients (67.9 ± 10.7 yrs, 80 men) who underwent CPX were recruited in this study. Renal functions were measured by eGFR and creatinine clearance (Ccr) using Cockroft-Gaut formula. Exercise capacity was presented as peak WR, peakVO2/kg, VO2/kg at anaerobic threshold (AT) and VE/VCO2 slope. Results: Serum creatinine was 0.94 ± 0.4 mg/dL. Ccr and eGFR were 68.1 ± 22.2 mL/min and 63.6 ± 17.9 mL/min/1.73 m2. Left ventricular ejection fraction was 58.2 ± 12.4%. Plasma brain natriuretic peptide (BNP) was 129 ± 193 pg/mL. Ccr was correlated with peakWR, peakVO2/kg and VE/VCO2 slope. But eGFR was not. AT was not correlated with both. Conclusion: Renal function, especially Ccr was correlated with peakVO2/Wt and VE/VCO2 slope.
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