Abstract| Volume 23, ISSUE 10, SUPPLEMENT , S77, October 2017

Reduction of Creatinine Clearance Is Associated With Frailty—Evaluation of the Exercise Capacity Using Cardiopulmonary Exercise Examination

      Background: The relationship renal function and exercise performance has been unclear yet. We estimated the effects of renal function on exercise performance by using the parameters of cardiopulmonary exercise testing (CPX). Methods: Consecutive 110 patients (67.9 ± 10.7 yrs, 80 men) who underwent CPX were recruited in this study. Renal functions were measured by eGFR and creatinine clearance (Ccr) using Cockroft-Gaut formula. Exercise capacity was presented as peak WR, peakVO2/kg, VO2/kg at anaerobic threshold (AT) and VE/VCO2 slope. Results: Serum creatinine was 0.94 ± 0.4 mg/dL. Ccr and eGFR were 68.1 ± 22.2 mL/min and 63.6 ± 17.9 mL/min/1.73 m2. Left ventricular ejection fraction was 58.2 ± 12.4%. Plasma brain natriuretic peptide (BNP) was 129 ± 193 pg/mL. Ccr was correlated with peakWR, peakVO2/kg and VE/VCO2 slope. But eGFR was not. AT was not correlated with both. Conclusion: Renal function, especially Ccr was correlated with peakVO2/Wt and VE/VCO2 slope.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Journal of Cardiac Failure
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect