Background: N-terminal pro-B type natriuretic peptide (NT-proBNP) has been introduced as a useful
parameter for assessing left ventricular (LV) function. We aimed to evaluate correlation
between NT-proBNP on the LV systolic and diastolic echocardiographic parameters in
mid-range heart failure so called “grey area”. Methods: NT-proBNP and echocardiography were measured within 24 hours were enrolled and cases
with less than 125 pg/mL of serum NT-proBNP or LVEF ≥ 50% or LVEF < 40% in echocardiography
were excluded. Results: Among total 617 patients (54% female, mean age 68.9 ± 12.7 years NT-proBNP levels
ranged from 125 to 35,000 pg/mL with a mean of 7194 pg/mL. NT-proBNP levels were significantly
correlated with EF by volumetry (r = 0.08, P = .045), left atrial volume index (r = 0.03, P = .50), transmitral E/mitral annular E′ (E/E′) (r = 0.17, P < .001), right ventricular systolic pressure (r = 0.20, P < .001) and LV mass index (r = 0.18, P < .001). NT-proBNP showed low sensitivities and specificity to determine high E/E′
ratio above 13 and high LAVI above 34 on cut-off values of the ROC curve (67.6% at
1360 pg/mL, 67.4% at 1382 pg/mL, respecitively). Conclusions: NT-proBNP was proved as a useful parameter for assessing LV diastolic in patients
with mid range heart failure.
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