Abstract| Volume 23, ISSUE 10, SUPPLEMENT , S75, October 2017

Time Dependent Change of Xanthine Oxidoreductase (XOR) Activity in Patients With Acute Heart Failure

      Background: The xanthine oxidoreductase (XOR) was one of a biomarker reflected oxidant stress. Method and Result: The plasma levels of XOR activity were measured in 57 AHF patients before starting treatment (day 1), 3 (day 3) and 14 (day 14) days after admission. The median plasma levels of XOR activity on admission was 158.0 pmol⋅h−1⋅mL−1 [interquartile range, 32.3–401.0 pmol⋅h−1⋅mL−1], those at day 3 was 17.3 pmol⋅h−1⋅mL−1 [8.7–69.9 pmol⋅h−1⋅mL−1] and those at day 14 was 30.5 pmol⋅h−1⋅mL−1 [7.9–83.6 pmol⋅h−1⋅mL−1]. XOR decreased rapidly and significantly from day 1 to day 3, whereas XOR did not decrease after day 3 (ANOVA, P < .001). Conclusion: The plasma levels of XOR activity decreased with the treatment of AHF. This is the first report regarding the time dependent change of XOR in AHF.
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