Background: Low brain-derived neurotrophic factor (BDNF) levels associate with pathogenesis of depression. Because depression increases risk of heart failure (HF), the pathogenic link between HF and depression has attracted clinical attention. We hypothesized that cardiac rehabilitation might be increase BDNF levels in association with improvement of depressive symptom in patients with HF. Methods and Results: We evaluated plasma BDNF levels before and after (3 month) cardiac rehabilitation in 49 patients. Plasma BDNF levels were significantly increased [2477 (1438–4340) vs 5268 (3126–7803) pg/mL: P < .001, Fig. 1] and depressive symptom was improved [beck depression inventory (BDI) score: 10.7 ± 8.2 vs 7.6 ± 5.6; P = .003]. The change of BDNF was significantly associated with change of BDI score (P = .01). Conclusion: Cardiac rehabilitation can improve the depressive symptom with increase of BDNF levels in patients with HF.
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