Introduction: Cardiac amyloidosis (CA) is characterized by regional variations from base to apex
in longitudinal strain (LS) using echocardiography. A relative apical sparing pattern
of LS is reproductive method of differentiating CA from other causes of left ventricular
hypertrophy. Methods: 40 consecutive patients suspected CA by echocardiography underwent thallium-201-chloride
and 99mTc-PYP SPECT. We evaluated apical sparing on nuclear cardiology using the each
percentage of left ventricular thickenings (17 segment) that were accumulated by quantitative
gated SPECT. We calculated the relative apical thickening score (average apical thickening/average
basal thickening + mid thickening). Results: Mean age of study population was 70 ± 12 years, and 70% were males. Six patients
had biopsy proven systemic amyloidosis. The average score in the group of CA was 1.07 ± 0.25
and the other was 0.78 ± 0.44 (P = .034). Cutoff value of the apical thickening score was 0.82 and the sensitivity
and specificity for diagnosing CA were 83% and 68%. Conclusions: In CA, the relative apical thickening score accumulated by SPECT expressed in a similar
pattern to that of echocardiography. We may predict likelihood of CA by adding the
score when we check SPECT image.
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