Background: Intra-aortic balloon pumping (IABP) provides potent supports on hemodynamic status
of patients with cardiac shock through decreasing end-diastolic pressure and increasing
cardiac output. We aimed to evaluate the impact of the timing of IABP induction on
clinical prognosis in AHF patients at very high risk. Methods and Results: Of 404 AHF patients who were urgently admitted to the intensive care unit, 60 patients
with both of left ventricular ejection fraction <35% and systolic blood pressure on
admission <100 mmHg were ultimately enrolled in this study. The study population were
divided into 3 groups depending on IABP use; the Early IABP group (induced at ≤3 days
after admission, n = 18), Late IABP group (≥4 days, n = 16) and Non-IABP group (n = 26).
Patient background on admission was not significantly different among 3 groups. However,
in-hospital mortality in the Early IABP group was 6%, that was significantly lower
than that in Late group (vs. 31%, P = .049) and in Non-IABP group (vs. 35%, P = .024). Additionally, hospital stay of patients who discharged alive in the Early
IABP group was significantly shorter than other 2 groups (21 [12–49] vs. 68 [26–93]
vs. 40 [24–64] days, P = .024). Conclusions: Early induction of IABP is one of the therapeutic options for improvement of in-hospital
prognosis in AHF patients at very high risk.
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