Background: Elevated blood urea nitrogen (BUN) has been shown to be closely related not only
to renal dysfunction but also neurohumoral activation in heart failure (HF), and also
reported to predict poor in-hospital and longterm outcomes in HF patients. In obese
HF patients who have relatively lower BNP levels and higher neurohumoral activation,
BUN may be greater significance. Methods and Results: We enrolled 53 overweight or obese patients with acute decompensated HF. (body mass
index >25 kg/dL/m2 at discharge). They were divided into 2 groups according to BUN at discharge (groupL;
BUN < 25 mg/dL n = 37, groupH; BUN >25 mg/dL n = 16). The composite endpoints were
all cause death and re-hospitalization for HF were compared between the groups. GroupH
had significantly higher older age, lower hemoglobin levels at discharge. During a
median follow-up period of 438 ± 408 days after discharge, the Kaplan-Meier curve
showed groupH had worse prognosis compared with groupL (Log-lank test P < .001) Multivariate analysis showed that BUN at discharge was a predictor of the
composite endpoints. (hazard ratio, 1.25; 95% confidence interval, 1.03 to 1.52; P < .03) independent of other parameter of renal function. Conclusion: In overweight or obese patients with acute decompensated HF, BUN at discharge may
be a useful predictor for adverse outcomes.
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Journal of Cardiac FailureAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
