We have developed a multi-scale 3-D heart simulator “UT-Heart”, which reproduces the
function of heart based on the molecular mechanisms of excitation-contraction coupling
process. Combined with the personalization technology, of this simulator. we tested
the capability of tailor-made heart model to reproduce the response to cardiac resynchronization
therapy (CRT) in a retrospective study. We created heart models of nine patients treated
by CRT based on the clinical data recorded before treatment. To each heart model,
we performed CRT simulation according to the actual protocol and compared the results
with clinical data. We found that simulated improvement in the maximum derivative
of ventricular pressure can predict the clinically observed improvement in the ejection
fraction. CRT simulation using tailor-made heart model can be a useful tool in clinical
decision making.
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