Abstract| Volume 23, ISSUE 10, SUPPLEMENT , S43, October 2017

Prediction of Cardiac Events in Patients with Hypertrophic Cardiomyopathy: A Cardiac Magnetic Resonance Imaging Study

      Background: Cardiac magnetic resonance imaging (CMR) which detects myocardial hypertrophy and fibrosis with high spatial resolution has been reported to be useful for risk stratification of patients with hypertrophic cardiomyopathy (HCM). Objective: We evaluated predictive value of CMR for cardiac events in patients with HCM. Methods: We divided 88 HCM patients who underwent CMR according to the presence or the absence of the cardiac events of cardiac death, ventricular arrhythmia and heart failure and compared the two groups. Furthermore, we conducted receiver-operating characteristics (ROC) analysis for the cardiac events. Results: Nine patients with the cardiac events demonstrated a significantly higher BNP level (811 ± 937 pg/ml vs. 136 ± 173 pg/ml, P = .001), thicker left ventricular (LV) wall (30 ± 0 mm vs. 21 ± 5 mm, P < .001), heavier LV mass (206 ± 121 g vs. 116 ± 50 g, P = .001) and larger late gadolinium enhancement (LGE) volume (15 ± 10%LV vs 6 ± 7%LV, P = .003) compared with 79 patients without the cardiac events. Areas under the ROC curves of LV wall thickness, BNP level, LV mass and LGE volume were 0.927, 0.878, 0.793 and 0.733, respectively. Conclusions: Degree of LV hypertrophy and LGE measured by CMR predicted the cardiac events. We need further evaluation to confirm the predictive value of CMR.
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