Objective: Neutrophil-to-lymphocyte ratio (NLR) is an inflammation marker that can be used to
detect atrial inflammatory changes, which may contribute to reduced left atrial (LA)
function and thrombosis. Methods: 183 PAF patients were studied. LA volume index, mitral flow velocity (A), and mitral
annular motion velocity were examined using transthoracic echocardiography. LA appendage
(LAA) area, LAA wall motion velocity, and presence of spontaneous echo contrast (SEC)
were examined using transesophageal echocardiography. Results: NLR of patients with cerebral embolism was significantly greater than in patients
without the disorder. A cut-off point of 2.5 for NLR had a sensitivity of 71% and
a specificity of 74% in predicting cerebral embolism. The patients with NLR > 2.5
had greater LA volume index or LAA area compared to the patients with NLR < 2.5. NLR
was an independent risk factor for SEC. NLR was significantly correlated with LAA
wall motion velocity in 153 patients without SEC and with LAA wall motion velocity
and LAA area, in 30 patients with SEC, but not with LA volume index, A, or mitral
annular motion velocity in both groups. Conclusion: In PAF patients, high NLR indicates thrombogenesis with a high degree of certainty
and is associated with reduced LAA contraction rather than with LA body function.
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