Abstract| Volume 23, ISSUE 10, SUPPLEMENT , S38-S39, October 2017

In Paroxysmal Atrial Fibrillation Patients, Neutrophil-to-lymphocyte Ratio Is More Associated with Left Atrial Appendage Than with Left Atrial Body

      Objective: Neutrophil-to-lymphocyte ratio (NLR) is an inflammation marker that can be used to detect atrial inflammatory changes, which may contribute to reduced left atrial (LA) function and thrombosis. Methods: 183 PAF patients were studied. LA volume index, mitral flow velocity (A), and mitral annular motion velocity were examined using transthoracic echocardiography. LA appendage (LAA) area, LAA wall motion velocity, and presence of spontaneous echo contrast (SEC) were examined using transesophageal echocardiography. Results: NLR of patients with cerebral embolism was significantly greater than in patients without the disorder. A cut-off point of 2.5 for NLR had a sensitivity of 71% and a specificity of 74% in predicting cerebral embolism. The patients with NLR > 2.5 had greater LA volume index or LAA area compared to the patients with NLR < 2.5. NLR was an independent risk factor for SEC. NLR was significantly correlated with LAA wall motion velocity in 153 patients without SEC and with LAA wall motion velocity and LAA area, in 30 patients with SEC, but not with LA volume index, A, or mitral annular motion velocity in both groups. Conclusion: In PAF patients, high NLR indicates thrombogenesis with a high degree of certainty and is associated with reduced LAA contraction rather than with LA body function.
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