Aim: To investigate a comparison of the aldosterone-blocking agents eplerenone and spironolactone
on cardiovascular outcomes in patients with heart failure (HF). Methods: Among prospectively enrolled 838 patients who were hospitalized for acute decompensated
HF, 90 patients treated with eplerenone were compared with propensity score matched
90 patients with spironolactone. The primary endpoint was a composite of cardiovascular
death and hospitalization and secondary endpoint was all course mortality. Results: During follow up (594 ± 317 days), primary events were occurred in 27 patients in
the eplerenone group (30.0%), 25 patients in the spironolactone group (27.8%). There
were no significant differences for the primary endpoint (log-rank, P = .956) and secondary endpoint (log-rank, P = .814) among 2 groups. Conclusion: Among Japanese population with HF, eplerenone and spironolactone have similar impact
on cardiovascular outcomes.
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