The age-related decline of circulating anabolic hormones in male is associated with
increased morbidity and mortality. It has been reported that anabolic deficiency is
associated with cachexia in patients with heart failure (HF). Thus, we aimed to investigate
the impact of testosterone on cardiac function and exercise capacity. We analyzed
consecutive 618 male patients with HF (age 65.9 years), who admitted to our hospital.
These patients were divided into 4 groups based on the serum levels of total testosterone
(TT): 1st (TT >631 ng/dl, n = 154), 2nd (462 < TT <631 ng/dl, n = 155), 3rd (300 < TT
<462 ng/dl, n = 156) and 4th (TT <300 ng/dl, n = 153) quartiles. We compared parameters
of echocardiography and cardiopulmonary exercise testing, and plasma levels of cardiac
troponin I among the four groups. Left ventricular ejection fraction, right ventricular
fractional area change, B-type natriuretic peptide did not differ among the four groups.
In contrast, the 4th quartile, compared to 1st, 2nd and 3rd groups, had higher levels
of troponin I and lower peak VO2 (troponin I, 57.4 vs. 21.4, 21.7, 33.4 pg/ml, P < .01; peak VO2 14.5 vs. 16.4, 15.8, 16.5 ml/kg/min, P < .05). Lower serum testosterone is associated with myocardial damage and lower exercise
capacity in male patients with heart failure.
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Journal of Cardiac FailureAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
