We prospectively investigated the predictive value of D-dimer and high-sensitivity
C-reactive protein (hsCRP) for 30-day mortality in 644 paroxysmal or persistent atrial
fibrillation patients (mean age of 76 yrs) hospitalized for worsening heart failure.
Results: Forty-nine deaths occurred during 30 days. Non-survivors were older (80 vs. 76 yrs,
P = .04), had a higher prevalence of NYHA class 4 (71 vs. 39%, P < .0001), higher N-terminal pro-B-type natriuretic peptide levels (8104 vs. 3922 pg/mL,
P < .0001), D-dimer (3.10 vs. 1.30 µg/mL, P < .0001), and hsCRP (15.6 vs. 4.88 mg/L, P < .0001) compared with survivors. Multivariate analysis revealed that D-dimer and
hsCRP were independently associated with deaths. 30-day mortality rates according
to the combination of D-dimer and hsCRP tertiles were shown in Figure. Conclusion: The combination of D-dimer and hsCRP may predict 30-day mortality in this population.
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