The patient was a 57-year-old woman who had undergone maintenance hemodialysis due
to diabetic nephropathy. She suddenly developed high fever of 40°C, lumbago and epigastralgia
with hypotension and was diagnosed as having septic shock requiring vasopressors and
endotoxin adsorption therapy. Laboratory test demonstrated severe inflammation and
methicillin sensitive Staphylococcus aureus was cultured from blood samples, but clear
source of infection was not detected. After the administration of specific intravenous
antibiotics, inflammatory data gradually declined, but 10 days later, she developed
high fever and pericarditis. Echocardiogram disclosed pericardial effusion and calcification
of the posterior mitral leaflet but vegetation was not detected. Although the aspiration
was negative for bacterial growth, we diagnosed her as bacterial pericarditis and
continued the administration of antibiotics for four weeks. Thereafter she got well
and discharge. One month later, she visited our hospital with anorexia and computed
tomography revealed a large pseudoaneurysm of the posterior left ventricular wall
just below the posterior mitral valve leaflet. She underwent emergent surgery. The
left ventricular aneurysm orifice was closed. If patients on hemodialysis become complicated
by long term fever, we need to pay attention to the onset of infective endocarditis.
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