Abstract| Volume 23, ISSUE 10, SUPPLEMENT , S26-S27, October 2017

Association between Spleen Volume and Clinical Outcome in Patients with Heart Failure

      Introduction: A small spleen has been recognized to have an association with in-host immunologic disturbances. C-reactive protein (CRP) is one of the markers of inflammatory mediators and the predictors for prognosis in patients with heart failure (HF). However, it is unclear the relationship among spleen volume, CRP, and prognosis in patients with HF. Methods: We retrospectively enrolled 102 consecutive patients who were admitted for acute decompensated HF at 2012 and who had a computed tomography. We calculated spleen volume index (SpVi) using the prolate ellipsoid formula. Patients were stratified into 3 groups based on the tertile quantile of SpV. We followed all-cause mortality during 743 ± 517 days. Cardiac death was defined as death for worsening HF, ventricular fibrillation and sudden death. Results: There was an inverse correlation SpVi and serum levels of CRP (R = −0.29, P < .05). Kaplan-Meier curves showed that large SpVi had higher survival rates from both all-cause mortality and cardiac death. In multivariate analysis, SpVi (HR = 0.98, 95% CI 0.97–0.99; P < .01) was an independent predictor for cardiac death. Conclusion: Spleen volume is related to serum level of CRP and clinical outcome in patients with HF.
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