Introduction: A small spleen has been recognized to have an association with in-host immunologic
disturbances. C-reactive protein (CRP) is one of the markers of inflammatory mediators
and the predictors for prognosis in patients with heart failure (HF). However, it
is unclear the relationship among spleen volume, CRP, and prognosis in patients with
HF. Methods: We retrospectively enrolled 102 consecutive patients who were admitted for acute
decompensated HF at 2012 and who had a computed tomography. We calculated spleen volume
index (SpVi) using the prolate ellipsoid formula. Patients were stratified into 3
groups based on the tertile quantile of SpV. We followed all-cause mortality during
743 ± 517 days. Cardiac death was defined as death for worsening HF, ventricular fibrillation
and sudden death. Results: There was an inverse correlation SpVi and serum levels of CRP (R = −0.29, P < .05). Kaplan-Meier curves showed that large SpVi had higher survival rates from
both all-cause mortality and cardiac death. In multivariate analysis, SpVi (HR = 0.98,
95% CI 0.97–0.99; P < .01) was an independent predictor for cardiac death. Conclusion: Spleen volume is related to serum level of CRP and clinical outcome in patients with
HF.
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Journal of Cardiac FailureAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
