Abstract| Volume 23, ISSUE 10, SUPPLEMENT , S16, October 2017

Early Prediction Model for Successful Recovery in Patients with Fulminant Myocarditis Supported with Venoarterial Extracorporeal Membrane Oxygenation

      Background: Little is known about the best timing and method for prediction of successful recovery in patients with fulminant myocarditis (FM) supported with venoarterial extracorporeal membrane oxygenation (VA-ECMO). Purpose: To develop a prediction model for a successful recovery in patients with FM supported with VA-ECMO. Methods: This was retrospective multicenter chart review. FM patients treated with VA-ECMO (n = 99, female, 42%) were enrolled. We defined recovery success as the successful VA-ECMO decannulation and subsequent discharge (S-group, n=46). The other patients were defined as recovery failure (F-group, n=53). Results: The median PCPS run time was 137 hours. At VA-ECMO initiation (0-hr), there was no significant difference in the left ventricular ejection fraction (LVEF) between the two groups. However, the AST concentration was significantly lower in the S-group than F-group. At 48-hr, the LVEF, increase in the LVEF, and reduction of AST from 0-hr were identified as independent predictors in the S-group. Finally, we developed an S-group prediction model comprising those three variables (area under the curve, 0.844; 95% CI, 0.745–0.944). Conclusions: We developed a prediction model for 48 hours after VA-ECMO initiation for a successful recovery in patients with FM. Our early prediction model may contribute to determining whether we should hold out VA-ECMO for a successful recovery or convert to other forms of mechanical circulatory support.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Journal of Cardiac Failure
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect