Background: Significance of placental growth factor (PlGF) in acute decompensated heart failure (ADHF) was not clear. Methods: We have studied consecutive 436 patients with ADHF admitted to our department from 2011 through 2014. Of 436 patients, 271 patients measured PlGF levels on day 1 were studied. The primary endpoints were all-cause death and cardiovascular (CV) death.Results: We divided into two groups according to PlGF quartiles. Crude Kaplan-Meier curves revealed that high PlGF group (quartile 4; ≥14.1 pg/ml) had worse prognosis than low PlGF group (quartile 1–3; <14.1 pg/ml) in all-cause death and CV death (Fig. 1). After adjustment for covariates, PlGF remained an independent predictor of all-cause death and CV death.Conclusions: PlGF on the first day of admission was an important predictor for long-term outcome in ADHF patients.
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