Abstract| Volume 23, ISSUE 10, SUPPLEMENT , S19, October 2017

The Beneficial Effects of Renal Transplantation on Uremic Cardiomyopathy

      Background & Purpose: Although uremic cardiomyopathy (UC) is often associated with end-stage renal disease (ESRD) characterized by left ventricular (LV) hypertrophy and reduced ejection fraction (EF), the optimal therapy for UC has not been established. This study tested the hypothesis that renal transplantation (RT) leads to improvement of LV remodeling/function. Methods: A total of 48 ESRD patients were divided into two groups: recipients who underwent RT (RT; n = 28) and hemodialysis continuation patients (HD; n = 20). RT patients were further divided into reduced-EF (<50%, REF, n = 10) and preserved-EF (>50%, PEF, n = 18) groups. The echocardiographic data were obtained at 1-, 6-, and 12-month after RT. The patients with ischemic heart disease were excluded. Results: In HD patients, we found no obvious change in LV mass index (LVMI), LV end-diastolic volume (LVEDV), and LVEF during follow-up. In RT patients, LVMI and LVEDV significantly decreased at 12-month after RT, in which decrease in LVMI was more evident in REF than that in PEF (-27 ± 5 and -8 ± 7% respectively, P < .05). The LVEF time-dependently increased in REF (from 46 ± 3 to 71 ± 4% during 12-month, P < .0001), albeit not obvious in PEF. Of note, the improvement of LVEF after RT had strong negative correlation with basal EF value (r = -0.92, P < .001). Conclusion: RT leads to LV reverse remodeling. The functional improvement of LV was more evident in UC recipients.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Journal of Cardiac Failure
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect