Abstract
Background
Until recently, transplantation from hepatitis C–positive donors was relatively contraindicated
as eradication of active hepatitis C previously required an interferon-based regimen
that has been associated with rejection in solid organ transplantation. New interferon-free
treatment regimens for hepatitis C have fewer adverse events and higher cure rates
than interferon-based regimens. Interferon-free regimens have been shown to be safe
in the liver transplantation literature, but little is known about the safety and
efficacy of treatment in heart transplantation.
Case Description and Discussion
Here we report a case of successful eradication of hepatitis C with a non–interferon-based
regimen using ledipasvir-sofosbuvir following combined orthotopic heart and liver
transplantation. Based on the prevalence of hepatitis C in the general population,
inclusion of hepatitis C–positive donors for heart transplantation can expand this
component of the donor pool 3- to 6-fold.
Conclusions
In carefully selected patients and recipients, inclusion of hepatitis C–positive donors
may allow for expansion of the donor pool.
Key Words
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References
- United Network for Organ Sharing based on OPTN data as of July 29, 2016.(Available at:) (Accessed August 8, 2016)
- Evolving epidemiology of hepatitis C virus.Clin Microbiol Infect. 2011; 17: 107-115
- The prevalence of hepatitis C virus infection in the United States, 1988 through 1994.N Engl J Med. 1999; 341: 556-562
- United Network for Organ Sharing based on OPTN data as of April 28, 2017.(Accessed May 1, 2017)
- Efficacy and safety of treatment of hepatitis C virus infection in renal transplant recipients.World J Gastroenterol. 2012; 18: 55-63
- Safety and efficacy of peginterferon-α2a plus ribavirin treatment in renal transplant recipients with chronic hepatitis C.J Hepatol. 2013; 58: 1096-1103
- Peginterferon alpha-2b and acute allograft failure in a heart transplant recipient.Ann Thorac Surg. 2010; 89: 1645-1647
- Ledipasvir and sofosbuvir for untreated HCV genotype 1 infection.N Engl J Med. 2014; 370: 1889-1898
Article info
Publication history
Published online: June 13, 2017
Accepted:
May 30,
2017
Received in revised form:
May 25,
2017
Received:
March 28,
2017
Identification
Copyright
© 2017 Elsevier Inc. All rights reserved.
