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Editorial Comment| Volume 20, ISSUE 3, P190-192, March 2014

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Clinical Implications of Weight Loss in Heart Failure

  • Carl J. Lavie
    Correspondence
    Reprint requests: Carl J. Lavie, MD, Medical Director, Cardiac Rehabilitation and Prevention, Director, Exercise Laboratories, John Ochsner Heart and Vascular Institute, Ochsner Clinical School–University of Queensland School of Medicine, 1514 Jefferson Highway, New Orleans, LA 70121-2483. Tel: (504) 842-1281; fax: (504) 842-5875.
    Affiliations
    John Ochsner Heart and Vascular Institute, Ochsner Clinical School–University of Queensland School of Medicine, New Orleans, Louisiana

    Department of Preventive Medicine, Pennington Biomedical Research Center, Louisiana State University Systems, Baton Rouge, Louisiana
    Search for articles by this author
  • Hector O. Ventura
    Affiliations
    John Ochsner Heart and Vascular Institute, Ochsner Clinical School–University of Queensland School of Medicine, New Orleans, Louisiana
    Search for articles by this author
Published:January 09, 2014DOI:https://doi.org/10.1016/j.cardfail.2014.01.002
Clinical Implications of Weight Loss in Heart Failure
Previous ArticleThe Effect of Weight Loss on Clinical Outcomes in Patients Implanted With a Cardiac Resynchronization Therapy Device—A MADIT-CRT Substudy
Next ArticleThe Israel Nationwide Heart Failure Survey: Sex Differences in Early and Late Mortality for Hospitalized Heart Failure Patients
      Clearly, overweight and obesity are increasing in epidemic proportions in the United States (US) and most of the Westernized world.
      • Sturm R.
      Increases in morbid obesity in the USA: 2000–05.
      Public Health. 2007; 121: 492-496
      , 
      • Lavie C.J.
      • Milani R.V.
      • Ventura H.O.
      Obesity and cardiovascular disease: risk factor, paradox, and impact of weight loss.
      J Am Coll Cardiol. 2009; 53: 1925-1932
      Obesity has many adverse effects on cardiovascular (CV) risk factors, including causing dyslipidemia, hypertension (HTN), and left ventricular (LV) hypertrophy (LVH), hyperglycemia/metabolic syndrome/type 2 diabetes mellitus, increasing inflammation, and reducing exercise capacity and fitness.
      • Lavie C.J.
      • Milani R.V.
      • Ventura H.O.
      Obesity and cardiovascular disease: risk factor, paradox, and impact of weight loss.
      J Am Coll Cardiol. 2009; 53: 1925-1932
      , 
      • Lavie C.J.
      • Alpert M.A.
      • Arena R.
      • Mehra M.R.
      • Milani R.V.
      • Ventura H.O.
      Impact of obesity and the obesity paradox on prevalence and prognosis in heart failure.
      J Am Coll Cardiol HF. 2013; 1: 93-102
      Because the CV risk factors are all directly responsible for increasing the risk of coronary heart disease (CHD), which is now probably the leading cause of heart failure (HF), this risk, along with HTN and LVH, which also adversely affect systolic and diastolic LV function, not surprisingly leads to obesity markedly increasing the risk of HF, with both preserved and reduced systolic function.
      • Lavie C.J.
      • Alpert M.A.
      • Arena R.
      • Mehra M.R.
      • Milani R.V.
      • Ventura H.O.
      Impact of obesity and the obesity paradox on prevalence and prognosis in heart failure.
      J Am Coll Cardiol HF. 2013; 1: 93-102
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      Article info

      Publication history

      Published online: January 09, 2014
      Accepted: January 2, 2014
      Received: January 2, 2014

      Footnotes

      See page 191 for disclosure information.

      Identification

      DOI: https://doi.org/10.1016/j.cardfail.2014.01.002

      Copyright

      © 2014 Elsevier Inc. Published by Elsevier Inc. All rights reserved.

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