Highlights
- •The prevalence of albuminuria in adults with established CHF remains unclear.
- •Among adults with CHF, 22.1% and 10.4% had micro- and macroalbuminuria, respectively
- •Adults with CHF had higher odds of albuminuria (odds ratio 1.89, 95% CI 1.59–2.26).
Abstract
Background
Numerous studies have reported an association between albuminuria and adverse outcomes
in adults with chronic heart failure (CHF). However, the prevalence of albuminuria
in adults with established CHF remains unclear.
Methods and Results
This study was a cross-sectional analysis of the National Health and Nutrition Examination
Survey (NHANES) 1999–2012. Adults aged ≥18 years were included, and diagnosis of CHF
was based on participant self-report. The primary outcome was the prevalence of microalbuminuria
(albumin-to-creatinine ratio 30–300 mg/g) and macroalbuminuria (albumin-to-creatinine
ratio >300 mg/g) in adults with CHF. The secondary outcome was the adjusted odds ratio
of any albuminuria in adults with and without CHF. During the study period, 37,961
adults did not have CHF and 1,214 adults had CHF. In adults with CHF, 22.1% (95% confidence
interval [CI] 19.6%–24.7%) had microalbuminuria and 10.4% (95% CI 8.1%–12.7%) macroalbuminuria.
In adjusted analyses, the odds of albuminuria in adults with CHF was 1.89-fold higher
(95% CI 1.59–2.26; P < .001) than in adults without CHF.
Conclusions
Taken together, albuminuria is more common in adults with CHF than in those without
CHF, even after adjustment for important demographic and clinical confounders.
Key Words
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Article info
Publication history
Published online: October 23, 2015
Accepted:
October 5,
2015
Received in revised form:
September 18,
2015
Received:
November 18,
2014
Identification
Copyright
© 2016 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
