Journal of Cardiac Failure
Volume 16, Issue 9 , Pages 769-776 , September 2010

Mast Cell Stabilization Decreases Cardiomyocyte and LV Function in Dogs With Isolated Mitral Regurgitation

  • Betty Pat, PhD

      Affiliations

    • Department of Medicine, University of Alabama at Birmingham (UAB), Birmingham, AL
    • ,
  • Cheryl Killingsworth, DVM, PhD

      Affiliations

    • Department of Medicine, University of Alabama at Birmingham (UAB), Birmingham, AL
    • ,
  • Yuanwen Chen, MD, PhD

      Affiliations

    • Department of Medicine, University of Alabama at Birmingham (UAB), Birmingham, AL
    • Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
    • ,
  • James D. Gladden, BS

      Affiliations

    • Department of Medicine, University of Alabama at Birmingham (UAB), Birmingham, AL
    • ,
  • Greg Walcott, MD

      Affiliations

    • Department of Medicine, University of Alabama at Birmingham (UAB), Birmingham, AL
    • ,
  • Pamela C. Powell, MS

      Affiliations

    • Department of Medicine, University of Alabama at Birmingham (UAB), Birmingham, AL
    • ,
  • Thomas Denney, PhD

      Affiliations

    • Department of Electrical Engineering, Auburn University, Auburn, AL
    • ,
  • Himanshu Gupta, MD

      Affiliations

    • Department of Medicine, University of Alabama at Birmingham (UAB), Birmingham, AL
    • ,
  • Ravi Desai, MD

      Affiliations

    • Department of Medicine, University of Alabama at Birmingham (UAB), Birmingham, AL
    • ,
  • Michael Tillson, DVM

      Affiliations

    • College of Veterinary Medicine, Auburn University, Auburn, AL
    • ,
  • A. Ray Dillon, DVM

      Affiliations

    • College of Veterinary Medicine, Auburn University, Auburn, AL
    • ,
  • Louis J. Dell'Italia, MD

      Affiliations

    • Department of Medicine, University of Alabama at Birmingham (UAB), Birmingham, AL
    • Department of Veteran Affairs, University of Alabama at Birmingham (UAB), Birmingham, AL
    • Corresponding Author InformationReprint requests: Louis J. Dell'Italia, MD, UAB Center for Heart Failure Research, Department of Medicine, Division of Cardiology, 434 BMR2, 901 19th Street South, Birmingham, AL 35294-2180. Tel: (205) 934-0850; Fax: (205) 996-2586.

Received 30 September 2009 ,Revised 4 May 2010 ,Accepted 6 May 2010.

References 

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  2. Dell'Italia LJ, Meng QC, Balcells E, Straeter-Knowlen IM, Hankes GH, Dillon R, et al. Increased ACE and chymase-like activity in cardiac tissue of dogs with chronic mitral regurgitation. Am J Physiol. 1995;269:H2065–H2073
  3. Dell'Italia LJ, Balcells E, Meng QC, Su X, Schultz D, Bishop SP, et al. Volume overload cardiac hypertrophy is unaffected by ACE inhibitor treatment in the dog. Am J Physiol. 1997;273:H961–H970
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 Supported by the Office of Research and Development, Medical Service, Department of Veteran Affairs (LJD) and National Heart, Lung and Blood Institute Grant Specialized Centers of Clinically Orientated Research grant in Cardiac Dysfunction P50HL077100.

 See page 776 for disclosure information.

PII: S1071-9164(10)00211-3

doi: 10.1016/j.cardfail.2010.05.005

Journal of Cardiac Failure
Volume 16, Issue 9 , Pages 769-776 , September 2010

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