Journal of Cardiac Failure
Volume 16, Issue 9 , Pages 786-796 , September 2010

Myocardial Function With Reduced Expression of the Sodium-Calcium Exchanger

  • Maria C. Jordan, MD

      Affiliations

    • Department of Physiology, David Geffen School of Medicine at UCLA, Los Angeles, CA
    • The Cardiovascular Research Laboratory, David Geffen School of Medicine at UCLA, Los Angeles, CA
    • Corresponding Author InformationReprint requests: Maria C. Jordan, MD, Department of Physiology, Room 53-231 CHS, David Geffen School of Medicine at UCLA, 10833 Le Conte Ave., Los Angeles, CA 90095-1751. Tel: 310-206-5538; Fax: 310-206-5661.
    • ,
  • Scott A. Henderson, PhD

      Affiliations

    • Department of Physiology, David Geffen School of Medicine at UCLA, Los Angeles, CA
    • The Cardiovascular Research Laboratory, David Geffen School of Medicine at UCLA, Los Angeles, CA
    • ,
  • Tieyan Han, MD

      Affiliations

    • Department of Physiology, David Geffen School of Medicine at UCLA, Los Angeles, CA
    • The Cardiovascular Research Laboratory, David Geffen School of Medicine at UCLA, Los Angeles, CA
    • ,
  • Michael C. Fishbein, MD

      Affiliations

    • Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA
    • ,
  • Kenneth D. Philipson, PhD

      Affiliations

    • Department of Physiology, David Geffen School of Medicine at UCLA, Los Angeles, CA
    • Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA
    • The Cardiovascular Research Laboratory, David Geffen School of Medicine at UCLA, Los Angeles, CA
    • ,
  • Kenneth P. Roos, PhD

      Affiliations

    • Department of Physiology, David Geffen School of Medicine at UCLA, Los Angeles, CA
    • The Cardiovascular Research Laboratory, David Geffen School of Medicine at UCLA, Los Angeles, CA

Received 15 September 2009 ,Revised 4 March 2010 ,Accepted 31 March 2010.

References 

  1. Philipson KD, Nicoll DA. Sodium-calcium exchange: a molecular perspective. Annu Rev Physiol. 2000;62:111–133
  2. Artman M. Sarcolemmal Na+-Ca2+ exchange activity and exchanger immunoreactivity in developing rabbit hearts. Am J Physiol Heart Circ Physiol. 1992;263:H1506–H1513
  3. Liu W, Yasui K, Opthof T, Ishiki R, Lee JK, Kamiya K, et al. Developmental changes of Ca2+ handling in mouse ventricular cells from early embryo to adulthood. Life Sci. 2002;71:1279–1292
  4. Kent RL, Rozich JD, McCollam PL, McDermott DE, Thacker UF, Menick DR, et al. Rapid expression of the Na+ Ca2+ exchanger in response to cardiac pressure overload. Am J Physiol Heart Circ Physiol. 1993;265:H1024–H1029
  5. Studer R, Reinecke H, Bilger J, Eschenhagen T, Bohm M, Hasenfuss G, et al. Gene expression of the cardiac Na+ Ca2+ exchanger in end stage human heart failure. Circ Res. 1994;75:443–453
  6. Hasenfuss G. Alterations of calcium-regulatory proteins in heart failure. Cardiovasc Res. 1998;37:279–289
  7. Houser SR, Piacentino V, Weisser J. Abnormalities of calcium cycling in the hypertrophied and failing heart. J Mol Cell Cardiol. 2000;32:1595–1607
  8. Roos KP, Jordan MC, Fishbein MC, Ritter MR, Friedlander M, Chang HC, et al. Hypertrophy and heart failure in mice overexpressing the cardiac sodium-calcium exchanger. J Card Fail. 2007;13:318–329
  9. Wakimoto K, Kobayashi K, Kuro-o M, Yao A, Iwamoto T, Yanaka N, et al. Targeted disruption of Na+/Ca2+ exchanger gene leads to cardiomyocyte apoptosis and defects in heartbeat. J Biol Chem. 2000;275:36991–36998
  10. Koushik SV, Wang J, Rogers R, Moskophidis D, Lambert NA, Creazzo TL, et al. Targeted inactivation of the sodium-calcium exchanger (Ncx1) results in the lack of a heartbeat and abnormal myofibrillar organization. FASEB J. 2001;15:1209–1211
  11. Reuter H, Henderson SA, Han T, Ross RS, Goldhaber JI, Phillipson KD. Na+ - Ca2+ exchanger is essential for the action of cardiac glycosides. Circ Res. 2002;90:305–308
  12. Henderson SA, Goldhaber JI, So JM, Han T, Motter C, Ngo A, et al. Functional adult myocardium in the absence of Na+-Ca2+ exchange: cardiac-specific knockout of NCX1. Circ Res. 2004;95:604–611
  13. Takimoto E, Yao A, Toko H, Takano H, Shimoyama M, Sonoda M, et al. Sodium calcium exchanger plays a key role in alteration of cardiac function in response to pressure overload. FASEB J. 2002;16:373–378
  14. Pott C, Goldhaber JI, Philipson KD. Genetic manipulation of cardiac Na+/Ca2+ exchange expression. Biochem Biophys Res Commun. 2004;322:1336–1340
  15. Pott C, Henderson SA, Goldhaber JI, Philipson KD. Na+/Ca2+ exchanger knockout mice: plasticity of cardiac excitation-contraction coupling. Ann N Y Acad Sci. 2007;1099:270–275
  16. Pott C, Ren X, Tran DX, Yang MJ, Henderson S, Jordan MC, et al. Mechanism of shortened action potential duration in Na+-Ca2+ exchanger knockout mice. Am J Physiol Cell Physiol. 2007;292:C968–C973
  17. Chu DK, Jordan MC, Kim JK, Couto MC, Roos KP. Comparing isoflurane with tribromoethanol anesthesia for echocardiographic phenotyping of transgenic mice. J Am Assoc Lab Animal Sci. 2006;45:8–13
  18. Tanaka N, Dalton N, Mao L, Rockman HA, Peterson KL, Gottshall KR, et al. Transthoracic echocardiography in models of cardiac disease in the mouse. Circulation. 1996;94:1109–1117
  19. Rockman HA, Ross RS, Harris AN, Knowlton KU, Steinhelper ME, Field LJ, et al. Segregation of atrial specific and inducible expression of an atrial natriuretic factor transgene and in vivo murine model of cardiac hypertrophy. Proc Natl Acad Sci U S A. 1991;88:8277–8281
  20. Jordan MC, Zheng Y, Ryazantsev S, Rozengurt N, Roos KP, Neufeld EF. Cardiac manifestations in the mouse model of mucopolysaccharidosis I. Mol Genet Metab. 2005;86:233–243
  21. Wehling-Henricks M, Jordan MC, Roos KP, Deng B, Tidball JG. Cardiomyopathy in dystrophin-deficient hearts is prevented by expression of a neuronal nitric oxide synthase transgene in the myocardium. Hum Mol Genet. 2005;14:1921–1933
  22. Imahashi K, Pott C, Goldhaber JI, Steenbergen C, Philipson KD, Murphy E. Cardiac-specific ablation of the Na+-Ca2+ exchanger confers protection against ischemia/reperfusion injury. Circ Res. 2005;97:916–921
  23. Komuro I, Ohtsuka M. Forefront of Na+/Ca2+ exchanger studies: role of Na+/Ca2+ exchanger—lessons from knockout mice. J Pharmacol Sci. 2004;96:23–26
  24. Pott C, Philipson KD, Goldhaber JI. Excitation-contraction coupling in Na+-Ca2+ exchanger knockout mice: reduced transsarcolemmal Ca2+ flux. Circ Res. 2005;97:1288–1295
  25. Elsherif L, Huang MS, Shai SY, Yang Y, Li RY, Chun J, et al. Combined deficiency of dystrophin and beta1 integrin in the cardiac myocyte causes myocardial dysfunction, fibrosis and calcification. Circ Res. 2008;102:1109–1117
  26. Bristow MR, Ginsburg R, Minobe W, Cubicciotti RS, Sageman WS, Lurie K, et al. Decreased catecholamine sensitivity and beta-adrenergic-receptor density in failing human hearts. N Engl J Med. 1982;307:205–211
  27. Lohse MJ, Engelhardt S, Eschenhagen T. What is the role of beta-adrenergic signaling in heart failure?. Circ Res. 2003;93:896–906
  28. Dostanic S, Servant N, Wang C, Chalifour LE. Chronic beta-adrenoreceptor stimulation in vivo decreased Bcl-2 and increased Bax expression but did not activate apoptotic pathways in mouse heart. Can J Physiol Pharmacol. 2004;82:167–174
  29. Zhang GX, Ohmori K, Nagai Y, Fujisawa Y, Nishiyama A, Abe Y, et al. Role of AT1 receptor in isoproterenol-induced cardiac hypertrophy and oxidative stress in mice. J Mol Cell Cardiol. 2007;42:804–811
  30. Langenbacher AD, Dong Y, Shu X, Choi J, Nicoll DA, Goldhaber JI, et al. Mutation in sodium-calcium exchanger 1 (NCX1) causes cardiac fibrillation in zebrafish. PNAS. 2005;102:17699–17704
  31. Patel U, Ravri BB. Short QT syndrome: a review. Cardiol Rev. 2009;17:300–303

 Dr. Philipson has received support from NIH HL-48509, Dr. Fishbein has received support from Piansky Family Trust and Dr. Roos has received support from Laubisch Endowment Funds.

 See page 796 for disclosure information.

PII: S1071-9164(10)00151-X

doi: 10.1016/j.cardfail.2010.03.012

Journal of Cardiac Failure
Volume 16, Issue 9 , Pages 786-796 , September 2010

Article Tools

* Image Usage & Resolution