Journal of Cardiac Failure
Volume 16, Issue 4 , Pages 301-307, April 2010

Relationship Between High Circulating Adiponectin With Bone Mineral Density and Bone Metabolism in Elderly Males With Chronic Heart Failure

  • Biljana Bozic, PhD

      Affiliations

    • Institute for Medical Research, Military Medical Academy, Belgrade, Serbia
    • Institute for Physiology and Biochemistry, University of Belgrade, Belgrade, Serbia
    • ,
  • Goran Loncar, MD, MSc

      Affiliations

    • Cardiology Department, Clinical Medical Center Zvezdara, Belgrade, Serbia
    • ,
  • Nenad Prodanovic, MD, PhD

      Affiliations

    • Clinic for Rheumatology and Clinical Immunology, Military Medical Academy, Belgrade, Serbia
    • ,
  • Zoran Radojicic, PhD

      Affiliations

    • Institute for Statistics, Faculty of Organizational Sciences, University of Belgrade, Belgrade, Serbia
    • ,
  • Vojkan Cvorovic, MD, MSc

      Affiliations

    • Clinical Hospital Center Zemun, University Clinical Center of Serbia, Belgrade, Serbia
    • ,
  • Sinisa Dimkovic, MD, PhD

      Affiliations

    • Cardiology Department, Clinical Medical Center Zvezdara, Belgrade, Serbia
    • ,
  • Vera Popovic-Brkic, MD, PhD, FRCP

      Affiliations

    • Institute of Endocrinology, University Clinical Center of Serbia, Belgrade, Serbia
    • Corresponding Author InformationReprint requests: Professor Vera Popovic-Brkic, MD, PhD, FRCP, Neuroendocrine Unit, Institute of Endocrinology, University Clinical Center of Serbia, Dr Subotic 13, 11000 Belgrade. Tel: +381 11. 3639702; Fax: +381 11 2685 357

Received 8 September 2009; received in revised form 11 December 2009; accepted 17 December 2009. published online 12 February 2010.

Abstract 

Background

The aim of the study was to investigate the associations of adiponectin and leptin to bone mass and bone specific surrogates in elderly males with chronic heart failure (CHF).

Methods and Results

Seventy-three males (mean age 68 ± 7 years) with stable mild to moderate CHF and 20 healthy individuals age- and body mass index–matching underwent dual energy x-ray absorptiometry measurements (bone mineral density (BMD) at hip and lumbar spine, total bone mineral content, and body composition); echocardiography; 6-minute walk test; grip strength; and biochemical assessment including adiponectin, leptin, bone specific surrogates (osteocalcin, β-CrossLaps, osteoprotegerin [OPG], receptor activator of nuclear factor κB ligand [RANKL]), parathyroid hormone, 25-hydroxy vitamin D, testosterone, sex hormone-binding globulin, and NT-pro-BNP. Serum adiponectin, osteocalcin, β-CrossLaps, OPG, RANKL, and parathyroid hormone were significantly increased in CHF patients, whereas 25-hydroxy vitamin D was significantly lower compared to healthy controls. The significant positive association was found between adiponectin level with osteocalcin, β-CrossLaps, OPG, and RANKL among CHF patients. In multivariate regression analysis, adiponectin was a significant determinant of total hip BMD, although the variance was small (r2 = 0.239), whereas leptin was determinant for total bone mineral content (r2 = 0.469) in patients with CHF.

Conclusions

Serum adiponectin is an independent predictor of BMD in elderly males with mild to moderate CHF, and showed a positive correlation to bone specific surrogates. Adiponectin, as cardioprotective hormone, seems to be able to exert a negative effect on bone mass in chronic heart failure. Further research is needed to confirm the potential for adipokines in the crosstalk between bone and energy metabolism in CHF patients.

Key Words: Adiponectin, leptin, bone, bone markers, heart failure

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 Supported by Serbian Ministry of Science (grant 145019), by Merck Sharp & Dohme unrestricted educational grant and by biochemical laboratory “Zavod za laboratorijsku dijagnostiku Konzilijum” Belgrade.

PII: S1071-9164(09)01235-4

doi:10.1016/j.cardfail.2009.12.015

Journal of Cardiac Failure
Volume 16, Issue 4 , Pages 301-307, April 2010

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