Journal of Cardiac Failure
Volume 16, Issue 3 , Pages 188-193 , March 2010

Continuous Versus Intermittent Infusion of Furosemide in Acute Decompensated Heart Failure

  • Margaret R. Thomson, PharmD, BCPS

      Affiliations

    • Baptist Hospital, Saint Thomas Health Services, Nashville, TN
    • ,
  • Jean M. Nappi, PharmD, BCPS

      Affiliations

    • South Carolina College of Pharmacy, Charleston, SC
    • Medical University of South Carolina, Charleston, SC
    • ,
  • Steven P. Dunn, PharmD, BCPS

      Affiliations

    • University of Kentucky Chandler Medical Center, Lexington, KY
    • ,
  • Ian B. Hollis, PharmD, BCPS

      Affiliations

    • University of North Carolina, School of Pharmacy and Hospitals, Chapel Hill, NC
    • ,
  • Jo E. Rodgers, PharmD, BCPS

      Affiliations

    • University of North Carolina, School of Pharmacy and Hospitals, Chapel Hill, NC
    • ,
  • Adrian B. Van Bakel, MD, PhD

      Affiliations

    • Medical University of South Carolina, Charleston, SC
    • Corresponding Author InformationReprint requests: Adrian B. Van Bakel MD, PhD, Division of Cardiology, Medical University of South Carolina, 25 Courtenay Dr. MSC 592, Charleston, SC 29425. Tel: 843-876-4790; Fax: 843-876-4809.

Received 19 March 2009 ,Revised 11 November 2009 ,Accepted 24 November 2009.

References 

  1. American Heart Association, American Stroke Association. Heart disease and stroke statistics—2008 update. Available from: http://www.americanheart.org/downloadable/heart/1200078608862HS_Stats%202008.final.pdf. Accessed December 11, 2009.
  2. Fonarow GC. Acute Decompensated Heart Failure National Registry (ADHERE) Advisory Committee. The acute decompensated heart failure national registry (ADHERE): opportunities to improve care of patients hospitalized with acute decompensated heart failure. Rev Cardiovasc Med. 2003;4(Suppl 7):S21–S30
  3. Domanski M, Norman J, Pitt B, Haigney M, Hanlon S, Peyster E. Diuretic use, progressive heart failure, and death in patients in the studies of left ventricular dysfunction (SOLVD). J Am Coll Cardiol. 2003;42:705–708
  4. Heart Failure Society of America. Evaluation and management of patients with acute decompensated heart failure. J Card Fail. 2006;12:e86–103
  5. Copeland JG, Campbell DW, Rlachetka JR, Salomon NW, Larson DF. Diuresis with continuous infusion of furosemide after cardiac surgery. Am J Surg. 1983;146:796–799
  6. Gulbis BE, Spencer AP. Efficacy and safety of a furosemide continuous infusion following cardiac surgery. Ann Pharmacother. 2006;40:1797–1803
  7. Dormans TP, VanMeyel JJ, Gerlag PG, Tan Y, Russel FG, Smiths P. Diuretic efficacy of high dose furosemide in severe heart failure: bolus injection versus continuous infusion. J Am Coll Cardiol. 1996;28:376–382
  8. Salvador DRK, Rey NR, Ramos GC, Punzalan FER. Continuous infusion versus bolus injection of loop diuretics in congestive heart failure. Cochrane Database of Systematic Reviews 2005, Issue 3. Art. No.: CD003178. DOI: 10.1002/14651858.CD003178.pub3
  9. Felker GM, O'Connor CM, Braunwald E for the Heart Failure Clinical Research Network Investigators. Loop diuretics in acute decompensated heart failure, necessary? evil?, a necessary evil?. Circ Heart Fail. 2009;2:56–62
  10. Ellison DH. Diuretic therapy and resistance in congestive heart failure. Cardiology. 2001;96:132–143
  11. Hammarlund MM, Odlind B, Paalzow LK. Acute tolerance to furosemide diuresis in humans. Pharmacokinetic-pharmacodynamic modeling. J Pharmacol Exp Ther. 1985;233:447–453
  12. Loon NR, Wilcox CS, Unwin RJ. Mechanism of impaired natriuretic response to furosemide during prolonged therapy. Kidney Intl. 1989;36:682–689
  13. Lahav M, Regev A, Ra'anani P, Theodor E. Intermittent administration of furosemide versus continuous infusion preceded by a loading dose for congestive heart failure. Chest. 1992;102:725–731
  14. Pivac N, Rumboldt Z, Sardelic S, Bagatin J, Polic S, Ljutic D, et al. Diuretic effects of furosemide infusion versus bolus injection in congestive heart failure. Int J Clin Pharm Res. 1998;121–128XVIII
  15. Kramer WG, Smith WB, Ferguson J, Serpas T, Grant AG, Black PK, et al. Pharmacodynamics of torsemide administered as an intravenous injection and as a continuous infusion with congestive heart failure. J Clin Pharm. 1996;36:265–270
  16. Aaser E, Gullestad L, Tollofsrud S, Lundberg J, Hall C, Djoseland O, et al. Effect of bolus injection versus continuous infusion of furosemide on diuresis and neurohormonal activation in patients with severe congestive heart failure. Scand J Clin Lab Invest. 1997;57:361–368

 The authors have no conflicts of interest.

PII: S1071-9164(09)01191-9

doi: 10.1016/j.cardfail.2009.11.005

Journal of Cardiac Failure
Volume 16, Issue 3 , Pages 188-193 , March 2010

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