Journal of Cardiac Failure
Volume 16, Issue 3 , Pages 230-238 , March 2010

Validation and Potential Mechanisms of Red Cell Distribution Width as a Prognostic Marker in Heart Failure

  • Larry A. Allen, MD, MHS

      Affiliations

    • Division of Cardiology, University of Colorado Denver, Aurora, CO
    • ,
  • G. Michael Felker, MD, MHS

      Affiliations

    • Department of Medicine, Duke University School of Medicine, Duke Clinical Research Institute, Durham, NC
    • ,
  • Mandeep R. Mehra, MBBS

      Affiliations

    • Department of Medicine, University of Maryland School of Medicine, Baltimore, MD
    • ,
  • Jun R. Chiong, MD, MPH

      Affiliations

    • Department of Medicine, Loma Linda University School of Medicine, Loma Linda, CA
    • ,
  • Stephanie H. Dunlap, DO

      Affiliations

    • Department of Internal Medicine, University of Cincinnati, Cincinnati, OH
    • ,
  • Jalal K. Ghali, MD

      Affiliations

    • Detroit Medical Center, Detroit, MI
    • ,
  • Daniel J. Lenihan, MD

      Affiliations

    • Department of Cardiology, University of Texas MD Anderson Cancer Center, Houston, TX
    • ,
  • Ron M. Oren, MD

      Affiliations

    • Mercy Iowa City, Iowa City, IA
    • ,
  • Lynne E. Wagoner, MD

      Affiliations

    • Greater Cincinnati Cardiovascular Consultants, Cincinnati, OH
    • ,
  • Todd A. Schwartz, DRPH

      Affiliations

    • Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC
    • ,
  • Kirkwood F. Adams Jr., MD

      Affiliations

    • Department of Medicine and Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC
    • Corresponding Author InformationReprint requests: Kirkwood F. Adams, Jr., MD, Associate Professor of Medicine and Radiology, UNC Heart Failure Program, 730 Martin Luther King Jr. Blvd, Suite 206, Chapel Hill, NC 27514. Tel: 919-966-2877; Fax: 919-966-2888.

Received 26 March 2009 ,Revised 3 November 2009 ,Accepted 6 November 2009.

References 

  1. Al-Ahmad A, Rand WM, Manjunath G, Konstam MA, Salem DN, Levey AS, et al. Reduced kidney function and anemia as risk factors for mortality in patients with left ventricular dysfunction. J Am Coll Cardiol. 2001;38:955–962
  2. Horwich TB, Fonarow GC, Hamilton MA, MacLellan WR, Borenstein J. Anemia is associated with worse symptoms, greater impairment in functional capacity and a significant increase in mortality in patients with advanced heart failure. J Am Coll Cardiol. 2002;39:1780–1786
  3. Mozaffarian D, Nye R, Levy WC. Anemia predicts mortality in severe heart failure: the prospective randomized amlodipine survival evaluation (PRAISE). J Am Coll Cardiol. 2003;41:1933–1939
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  5. Felker GM, Gattis WA, Leimberger JD, Adams KF, Cuffe MS, Gheorghiade M, et al. Usefulness of anemia as a predictor of death and rehospitalization in patients with decompensated heart failure. Am J Cardiol. 2003;92:625–628
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 Supported by the STAMINA-HFP and UNITE-HF Biomarker registries were funded by Amgen, Inc (Thousand Oaks, CA).

PII: S1071-9164(09)01176-2

doi: 10.1016/j.cardfail.2009.11.003

Journal of Cardiac Failure
Volume 16, Issue 3 , Pages 230-238 , March 2010

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