Journal of Cardiac Failure
Volume 15, Issue 9 , Pages 747-755 , November 2009

Levels of Circulating Pro-angiogenic Cells Predict Cardiovascular Outcomes in Patients With Chronic Heart Failure

  • Giovanna Balconi, BSc

      Affiliations

    • Department of Cardiovascular Research, Mario Negri Institute for Pharmacological Research, Milano, Italy
    • Equally contributed to the study.
    • ,
  • Ralf Lehmann, MD

      Affiliations

    • Department of Cardiology, Johann Wolfgang Goethe–University Frankfurt, Frankfurt, Germany
    • Equally contributed to the study.
    • ,
  • Fabio Fiordaliso, PhD

      Affiliations

    • Department of Cardiovascular Research, Mario Negri Institute for Pharmacological Research, Milano, Italy
    • ,
  • Birgit Assmus, MD

      Affiliations

    • Department of Cardiology, Johann Wolfgang Goethe–University Frankfurt, Frankfurt, Germany
    • ,
  • Stefanie Dimmeler, PhD

      Affiliations

    • Department of Cardiology, Johann Wolfgang Goethe–University Frankfurt, Frankfurt, Germany
    • ,
  • Patrizio Sarto, MD

      Affiliations

    • Ospedale Civile, Mirano, Italy
    • ,
  • Emanuele Carbonieri, MD

      Affiliations

    • Ospedale Civile, San Bonifacio, Verona, Italy
    • ,
  • Alessandra Gualco, MD

      Affiliations

    • Fondazione S Maugeri, Pavia, Italy
    • ,
  • Carlo Campana, MD

      Affiliations

    • IRCCS S Matteo Pavia, Italy
    • ,
  • Laura Angelici, MS

      Affiliations

    • Department of Cardiovascular Research, Mario Negri Institute for Pharmacological Research, Milano, Italy
    • ,
  • Serge Masson, PhD

      Affiliations

    • Department of Cardiovascular Research, Mario Negri Institute for Pharmacological Research, Milano, Italy
    • ,
  • Salman Aa Mohammed, MS

      Affiliations

    • Department of Cardiovascular Research, Mario Negri Institute for Pharmacological Research, Milano, Italy
    • ,
  • Elisabetta Dejana, BIOL D

      Affiliations

    • Vascular Biology Unit, FIRC Institute of Molecular Oncology, Milano, Italy
    • Mario Negri Institute for Pharmacological Research, Milano, Italy
    • Department of Biomolecular Sciences and Biotechnologies, School of Sciences, University of Milano, Milano, Italy
    • ,
  • Marco Gorini, MS

      Affiliations

    • Centro Studi ANMCO, Firenze, Italy
    • ,
  • Andreas M. Zeiher, MD

      Affiliations

    • Department of Cardiology, Johann Wolfgang Goethe–University Frankfurt, Frankfurt, Germany
    • ,
  • Roberto Latini, MD

      Affiliations

    • Department of Cardiovascular Research, Mario Negri Institute for Pharmacological Research, Milano, Italy
    • Department of Medicine, New York Medical College, Valhalla, NY
    • Corresponding Author InformationReprint requests: Roberto Latini, Dept. of Cardiovascular Research, Mario Negri Institute for Pharmacological Research, via La Masa 19, 20156 Milano, Italy. Tel: +39 0239 014454; Fax: +39 0233 200049.
    • ,
  • The GISSI-HF Investigators

Received 24 October 2008 ,Revised 17 April 2009 ,Accepted 21 May 2009.

References 

  1. Vasa M, Fichtlscherer S, Aicher A, et al. Number and migratory activity of circulating endothelial progenitor cells inversely correlate with risk factors for coronary artery disease. Circ Res. 2001;89:E1–E7
  2. Loomans CJ, de Koning EJ, Staal FJ, et al. Endothelial progenitor cell dysfunction: a novel concept in the pathogenesis of vascular complications of type 1 diabetes. Diabetes. 2004;53:195–199
  3. Tepper OM, Galiano RD, Capla JM, et al. Human endothelial progenitor cells from type II diabetics exhibit impaired proliferation, adhesion, and incorporation into vascular structures. Circulation. 2002;106:2781–2786
  4. Hill JM, Zalos G, Halcox JP, et al. Circulating endothelial progenitor cells, vascular function, and cardiovascular risk. N Engl J Med. 2003;348:593–600
  5. Schmidt-Lucke C, Rossig L, Fichtlscherer S, et al. Reduced number of circulating endothelial progenitor cells predicts future cardiovascular events: proof of concept for the clinical importance of endogenous vascular repair. Circulation. 2005;111:2981–2987
  6. Werner N, Kosiol S, Schiegl T, et al. Circulating endothelial progenitor cells and cardiovascular outcomes. N Engl J Med. 2005;353:999–1007
  7. Heeschen C, Aicher A, Lehmann R, et al. Erythropoietin is a potent physiologic stimulus for endothelial progenitor cell mobilization. Blood. 2003;102:1340–1346
  8. Landmesser U, Engberding N, Bahlmann FH, et al. Statin-induced improvement of endothelial progenitor cell mobilization, myocardial neovascularization, left ventricular function, and survival after experimental myocardial infarction requires endothelial nitric oxide synthase. Circulation. 2004;110:1933–1939
  9. Valgimigli M, Rigolin GM, Fucili A, et al. CD34+ and endothelial progenitor cells in patients with various degrees of congestive heart failure. Circulation. 2004;110:1209–1212
  10. Nonaka-Sarukawa M, Yamamoto K, Aoki H, et al. Circulating endothelial progenitor cells in congestive heart failure. Int J Cardiol. 2007;119:344–348
  11. Kissel CK, Lehmann R, Assmus B, et al. Selective functional exhaustion of hematopoietic progenitor cells in the bone marrow of patients with postinfarction heart failure. J Am Coll Cardiol. 2007;49:2341–2349
  12. Michowitz Y, Goldstein E, Wexler D, Sheps D, Keren G, George J. Circulating endothelial progenitor cells and clinical outcome in patients with congestive heart failure. Heart. 2007;93:1046–1050
  13. Latini R, Masson S, Anand I, et al. Effects of valsartan on circulating brain natriuretic peptide and norepinephrine in symptomatic chronic heart failure: the Valsartan Heart Failure Trial (Val-HeFT). Circulation. 2002;106:2454–2458
  14. Asahara T, Masuda H, Takahashi T, et al. Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization. Circ Res. 1999;85:221–228
  15. Carmeliet P. Mechanisms of angiogenesis and arteriogenesis. Nat Med. 2000;6:389–395
  16. Schmidt A, Brixius K, Bloch W. Endothelial precursor cell migration during vasculogenesis. Circ Res. 2007;101:125–136
  17. Asahara T, Murohara T, Sullivan A, et al. Isolation of putative progenitor endothelial cells for angiogenesis. Science. 1997;275:964–967
  18. Rehman J, Li J, Orschell CM, March KL. Peripheral blood “endothelial progenitor cells” are derived from monocyte/macrophages and secrete angiogenic growth factors. Circulation. 2003;107:1164–1169
  19. Dome B, Dobos J, Tovari J, et al. Circulating bone marrow-derived endothelial progenitor cells: characterization, mobilization, and therapeutic considerations in malignant disease. Cytometry A. 2008;73:186–193
  20. Yoder MC, Mead LE, Prater D, et al. Redefining endothelial progenitor cells via clonal analysis and hematopoietic stem/progenitor cell principals. Blood. 2007;109:1801–1809
  21. Urbich C, Dimmeler S. Endothelial progenitor cells: characterization and role in vascular biology. Circ Res. 2004;95:343–353
  22. Shantsila E, Watson T, Lip GY. Endothelial progenitor cells in cardiovascular disorders. J Am Coll Cardiol. 2007;49:741–752
  23. Aicher A, Heeschen C, Mildner-Rihm C, et al. Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells. Nat Med. 2003;9:1370–1376
  24. Leone AM, Rutella S, Bonanno G, et al. Mobilization of bone marrow-derived stem cells after myocardial infarction and left ventricular function. Eur Heart J. 2005;26:1196–1204
  25. Thum T, Fraccarollo D, Schultheiss M, Froese S, Galuppo P, Widder JD, et al. Endothelial nitric oxide synthase uncoupling impairs endothelial progenitor cell mobilization and function in diabetes. Diabetes. 2007;56:666–674
  26. Sarto P, Balducci E, Balconi G, et al. Effects of exercise training on endothelial progenitor cells in patients with chronic heart failure. J Card Fail. 2007;13:701–708
  27. Laufs U, Werner N, Link A, et al. Physical training increases endothelial progenitor cells, inhibits neointima formation, and enhances angiogenesis. Circulation. 2004;109:220–226
  28. Rehman J, Li J, Parvathaneni L, et al. Exercise acutely increases circulating endothelial progenitor cells and monocyte-/macrophage-derived angiogenic cells. J Am Coll Cardiol. 2004;43:2314–2318

 This work stems from the European Vascular Genomics Network (http://www.evgn.org), a Network of Excellence supported by the European Community's sixth Framework Programme for Research Priority 1 “Life sciences, genomics and biotechnology for health” (contract no. LSHM-CT-2003-503254), and the Consortium Agreement European Community “Heart failure and cardiac repair,” IP 018630.

PII: S1071-9164(09)00187-0

doi: 10.1016/j.cardfail.2009.05.011

Journal of Cardiac Failure
Volume 15, Issue 9 , Pages 747-755 , November 2009

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