Journal of Cardiac Failure
Volume 15, Issue 7 , Pages 593-599 , September 2009

Glycemic Status and Incident Heart Failure in Elderly Without History of Diabetes Mellitus: The Health, Aging, and Body Composition Study

  • Andreas Kalogeropoulos, MD

      Affiliations

    • Emory University, Atlanta, GA
    • ,
  • Vasiliki Georgiopoulou, MD

      Affiliations

    • Emory University, Atlanta, GA
    • ,
  • Tamara B. Harris, MD, MPH

      Affiliations

    • National Institute of Aging, National Institutes of Health, Bethesda, MD
    • ,
  • Stephen B. Kritchevsky, PhD

      Affiliations

    • Wake Forest University, Winston-Salem, NC
    • ,
  • Douglas C. Bauer, MD

      Affiliations

    • University of California San Francisco, San Francisco, CA
    • ,
  • Andrew L. Smith, MD

      Affiliations

    • Emory University, Atlanta, GA
    • ,
  • Elsa Strotmeyer, PhD, MPH

      Affiliations

    • University of Pittsburgh, Pittsburgh, PA
    • ,
  • Anne B. Newman, MD, MPH

      Affiliations

    • University of Pittsburgh, Pittsburgh, PA
    • ,
  • Peter W.F. Wilson, MD

      Affiliations

    • Emory University, Atlanta, GA
    • ,
  • Bruce M. Psaty, MD, PhD

      Affiliations

    • University of Washington, Seattle, WA
    • ,
  • Javed Butler, MD, MPH

      Affiliations

    • Emory University, Atlanta, GA
    • Corresponding Author InformationCorrespondence to: Javed Butler, MD, MPH, Cardiology Division, Emory University Hospital, 1365 Clifton Road, NE, Suite AT430, Atlanta, GA 30322. Tel: (404) 778-5273; Fax: (404) 778-5285.
    • ,
  • Health ABC Study

Received 16 December 2008 ,Revised 26 February 2009 ,Accepted 3 March 2009.

References 

  1. Nichols GA, Gullion CM, Koro CE, Ephross SA, Brown JB. The incidence of congestive heart failure in type 2 diabetes: an update. Diabetes Care. 2004;27:1879–1884
  2. Ingelsson E, Sundstrom J, Arnlov J, Zethelius B, Lind L. Insulin resistance and risk of congestive heart failure. JAMA. 2005;294:334–341
  3. Thrainsdottir IS, Aspelund T, Thorgeirsson G, Gudnason V, Hardarson T, Malmberg K, et al. The association between glucose abnormalities and heart failure in the population-based Reykjavik study. Diabetes Care. 2005;28:612–616
  4. Bell DS. Heart failure: the frequent, forgotten, and often fatal complication of diabetes. Diabetes Care. 2003;26:2433–2441
  5. Thrainsdottir IS, Aspelund T, Gudnason V, Malmberg K, Sigurdsson G, Thorgeirsson G, et al. Increasing glucose levels and BMI predict future heart failure experience from the Reykjavik Study. Eur J Heart Fail. 2007;9:1051–1057
  6. Witteles RM, Fowler MB. Insulin-resistant cardiomyopathy clinical evidence, mechanisms, and treatment options. J Am Coll Cardiol. 2008;51:93–102
  7. Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care. 1997;20:1183–1197
  8. World Health Organization . Definition, diagnosis and classification of diabetes mellitus and its complications. Geneva: World Health Organization; 1999;
  9. Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care. 2003;26(Suppl 1):S5–S20
  10. Schianca GPC, Rossi A, Sainaghi PP, Maduli E, Bartoli E. The significance of impaired fasting glucose versus impaired glucose tolerance: importance of insulin secretion and resistance. Diabetes Care. 2003;26:1333–1337
  11. Hanefeld M, Koehler C, Henkel E, Fuecker K, Schaper F, Temelkova-Kurktschiev T. Post-challenge hyperglycaemia relates more strongly than fasting hyperglycaemia with carotid intima-media thickness: the RIAD Study. Risk factors in impaired glucose tolerance for atherosclerosis and diabetes. Diabet Med. 2000;17:835–840
  12. Held C, Gerstein HC, Yusuf S, Zhao F, Hilbrich L, Anderson C, et al. Glucose levels predict hospitalization for congestive heart failure in patients at high cardiovascular risk. Circulation. 2007;115:1371–1375
  13. Butler J, Kalogeropoulos A, Georgiopoulou V, Belue R, Rodondi N, Garcia M, et al. Incident heart failure prediction in the elderly: The Health ABC Heart Failure Score. Circ Heart Fail. 2008;1:125–133
  14. Nichols GA, Hillier TA, Erbey JR, Brown JB. Congestive heart failure in type 2 diabetes: prevalence, incidence, and risk factors. Diabetes Care. 2001;24:1614–1619
  15. Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection . Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA. 2001;285:2486–2497
  16. Mokdad AH, Bowman BA, Ford ES, Vinicor F, Marks JS, Koplan JP. The continuing epidemics of obesity and diabetes in the United States. JAMA. 2001;286:1195–1200
  17. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412–419
  18. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2008;31(Suppl 1):S55–S60
  19. Kenchaiah S, Evans JC, Levy D, Wilson PW, Benjamin EJ, Larson MG, et al. Obesity and the risk of heart failure. N Engl J Med. 2002;347:305–313
  20. Wilson PW, McGee DL, Kannel WB. Obesity, very low density lipoproteins, and glucose intolerance over fourteen years: The Framingham Study. Am J Epidemiol. 1981;114:697–704
  21. An D, Rodrigues B. Role of changes in cardiac metabolism in development of diabetic cardiomyopathy. Am J Physiol Heart Circ Physiol. 2006;291:H1489–H1506
  22. Fang ZY, Yuda S, Anderson V, Short L, Case C, Marwick TH. Echocardiographic detection of early diabetic myocardial disease. J Am Coll Cardiol. 2003;41:611–617
  23. Galderisi M. Diastolic dysfunction and diabetic cardiomyopathy: evaluation by Doppler echocardiography. J Am Coll Cardiol. 2006;48:1548–1551
  24. Guerci B, Kearney-Schwartz A, Bohme P, Zannad F, Drouin P. Endothelial dysfunction and type 2 diabetes. Part 1: physiology and methods for exploring the endothelial function. Diabetes Metab. 2001;27:425–434
  25. Lopaschuk GD. Metabolic abnormalities in the diabetic heart. Heart Fail Rev. 2002;7:149–159
  26. Young ME, McNulty P, Taegtmeyer H. Adaptation and maladaptation of the heart in diabetes: Part II: potential mechanisms. Circulation. 2002;105:1861–1870
  27. Lopaschuk GD, Stanley WC. Glucose metabolism in the ischemic heart. Circulation. 1997;95:313–315
  28. Bhatia RS, Tu JV, Lee DS, Austin PC, Fang J, Haouzi A, et al. Outcome of heart failure with preserved ejection fraction in a population-based study. N Engl J Med. 2006;355:260–269

 Supported in part by the Intramural Research Program of the National Institute of Aging, National Institutes of Health, Bethesda, MD, and by grants N01-AG-6-2101, N01-AG-6-2103, and N01-AG-6-2106.

PII: S1071-9164(09)00085-2

doi: 10.1016/j.cardfail.2009.03.001

Journal of Cardiac Failure
Volume 15, Issue 7 , Pages 593-599 , September 2009

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