Journal of Cardiac Failure
Volume 15, Issue 6 , Pages 540-548 , August 2009

Left Ventricle Radio-frequency Ablation in the Rat: A New Model of Heart Failure due to Myocardial Infarction Homogeneous in Size and Low in Mortality

  • Ednei L. Antonio

      Affiliations

    • Department of Physiology, Cardiovascular Division, Federal University of São Paulo (UNIFESP), São Paulo, Brazil
    • ,
  • Alexandra A. Dos Santos

      Affiliations

    • Department of Medicine, Cardiology Division, Federal University of São Paulo (UNIFESP), São Paulo, Brazil
    • ,
  • Sérgio R.R. Araujo

      Affiliations

    • Department of Pathology, Federal University of São Paulo (UNIFESP), São Paulo, Brazil
    • ,
  • Danilo S. Bocalini

      Affiliations

    • Department of Physiology, Cardiovascular Division, Federal University of São Paulo (UNIFESP), São Paulo, Brazil
    • ,
  • Leonardo dos Santos

      Affiliations

    • Department of Medicine, Cardiology Division, Federal University of São Paulo (UNIFESP), São Paulo, Brazil
    • ,
  • Guilherme Fenelon

      Affiliations

    • Department of Medicine, Cardiology Division, Federal University of São Paulo (UNIFESP), São Paulo, Brazil
    • ,
  • Marcelo F. Franco

      Affiliations

    • Department of Pathology, Federal University of São Paulo (UNIFESP), São Paulo, Brazil
    • ,
  • Paulo J.F. Tucci

      Affiliations

    • Department of Physiology, Cardiovascular Division, Federal University of São Paulo (UNIFESP), São Paulo, Brazil
    • Corresponding Author InformationReprint requests: Paulo J. F. Tucci, MD, PhD, R. Estado de Israel 181/94 CEP: 04022-000, São Paulo, Brazil. Tel-Fax: (5511) 5573-7820.

Received 30 May 2008 ,Revised 21 January 2009 ,Accepted 21 January 2009.

References 

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  19. Jain M, Liao R, Ngoy S, Whittaker P, Apstein CS, Eberli FR. Angiotensin II receptor blockade attenuates the deleterious effects of exercise training on post-MI ventricular remodelling in rats. Cardiovasc Res. 2000;46:66–72
  20. Ehlert FA, Goldberger JJ. Cellular and pathophysiological mechanisms of ventricular arrhythmias in acute ischemia and infarction. Pacing Clin Electrophysiol. 1997;20:966–975
  21. Simmers T, de Bakker JT, Coronel R, Wittkampf FHM, van Capelle FJ, Janse MJ, et al. Effects of intracavitary blood flow and electrode-target distance on radiofrequency power required for transient conduction block in a Langendorff-perfused canine model. J Am Coll Cardiol. 1998;31:231–235
  22. D'Avila A, Gutierrez P, Scanavacca M, Reddy V, Lustgarten DL, Sosa E, et al. Effects of radiofrequency pulses delivered in the vicinity of the coronary arteries: implications for nonsurgical transthoracic epicardial catheter ablation to treat ventricular tachycardia. PACE. 2002;25:1488–1495
  23. Fuller IA, Wood MA. Intramural coronary vasculature prevents transmural radiofrequency lesions formation: implications for linear ablation. Circulation. 2003;107:1797–1803

 Supported by Fundação de Amparo à Pesquisa do Estado de São Paulo, Ministério da Ciência e Tecnologia (CNPq), Universidade Federal de São Paulo.

PII: S1071-9164(09)00029-3

doi: 10.1016/j.cardfail.2009.01.007

Journal of Cardiac Failure
Volume 15, Issue 6 , Pages 540-548 , August 2009

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