Genetic Evaluation of Cardiomyopathy—A Heart Failure Society of America Practice Guideline

Received 5 November 2008; received in revised form 22 January 2009; accepted 26 January 2009.

Substantial progress has been made recently in understanding the genetic basis of cardiomyopathy. Cardiomyopathies with known genetic cause include hypertrophic (HCM), dilated (DCM), restrictive (RCM), arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) and left ventricular noncompaction (LVNC). HCM, DCM, and RCM have been recognized as distinct clinical entities for decades, whereas ARVD/C and LVNC are relative newcomers to the field. Hence the clinical and genetic knowledge for each cardiomyopathy varies, as do the recommendations and strength of evidence.

1 Cardiovascular Division, University of Miami Miller School of Medicine, Miami, Florida

2 Division of Cardiology, University of Colorado Health Sciences Center, Denver, Colorado

3 Adult Medical Genetics Program, University of Colorado Health Sciences Center, Denver, Colorado

4 Howard Hughes Medical Institute and Cardiovascular Genetics Center of Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts

5 Division of Pediatric Cardiology, Baylor College of Medicine, Houston, Texas

Reprint requests: Ray E. Hershberger, MD, University of Miami, Miller School of Medicine, Cardiovascular Division, PO Box 016960, Miami, FL 33101-5138.

No conflicts of interest and no sources of funding disclosed.

PII: S1071-9164(09)00028-1

doi:10.1016/j.cardfail.2009.01.006

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