Journal of Cardiac Failure
Volume 14, Issue 8 , Pages 670-675 , October 2008

Predictors of Mortality From Pump Failure and Sudden Cardiac Death in Patients With Systolic Heart Failure and Left Ventricular Dyssynchrony: Results of the CARE-HF Trial

  • Barry F. Uretsky, MD

      Affiliations

    • Cardiology Division, UTMB, Galveston, Texas
    • Corresponding Author InformationReprint requests: Barry F. Uretsky, MD, 1001 Townson Avenue, P.O. Box 17006, Fort Smith, AR 72917-7006.
    • ,
  • Kristian Thygesen, MD

      Affiliations

    • Aarhus University Hospital, Aarhus, Denmark
    • ,
  • Jean-Claude Daubert, MD

      Affiliations

    • Department of Cardiology, Hopital Pontchaillou, Rennes, France
    • ,
  • Erland Erdmann, MD

      Affiliations

    • Klinik III fur Innere Medizin der Universitat zu Koln; Cologne, Germany
    • ,
  • Nick Freemantle, PhD

      Affiliations

    • University of Birmingham, Edgbaston, United Kingdom
    • ,
  • Daniel Gras, MD

      Affiliations

    • Nouvelles Cliniques Nantaises; Nantes, France
    • ,
  • Lukas Kappenberger, MD

      Affiliations

    • Division of Cardiology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    • ,
  • Luigi Tavazzi, MD

      Affiliations

    • Istituto di Ricovero e Cura a Carratere Scientifico, Policlinico San Matteo, Pavia, Italy
    • ,
  • John G.F. Cleland, MD

      Affiliations

    • Department of Cardiology, Castle Hill Hospital, Kingston-upon-Hull, United Kingdom

Received 6 September 2007 ,Revised 23 May 2008 ,Accepted 2 June 2008.

References 

  1. Cazeau S, Leclerq C, Larvergne T, et al. Effects of multisite biventricular pacing in patients with heart failure and intraventricular conduction delay. N Engl J Med. 2001;344:873–880
  2. Abraham WT, Fisher WG, Smith AL, et al. Combined cardiac resynchronization in chronic heart failure. N Engl J Med. 2002;346:1845–1853
  3. Bristow MR, Saxon LA, Boehmer J, et al. Cardiac-resynchronization therapy with or without an implantable defibrillator in advanced chronic heart failure. N Engl J Med. 2004;350:2140–2150
  4. Cleland JGF, Daubert J-C, Erdmann E, et al. The effect of cardiac resynchronization on morbidity and mortality in heart failure. N Engl J Med. 2005;352:1539–1549
  5. Cleland JGF, Daubert J-C, Erdmann E, et al. Longer-term effects of cardiac resynchronization therapy on mortality in heart failure [the Cardiac Resynchronization-Heart Failure (CARE-HF) trial extension phase. Eur J Heart Fail. 2006;27:1928–1932
  6. Cleland JGF, Daubert J-C, Erdmann E, et al. The CARE-HF Study (CArdiac Resynchronization in Heart Failure): rationale, design, and endpoints. Eur J Heart Fail. 2001;3:481–489
  7. Harrell FE, Lee KL, Mark DB. Tutorial in biostatistics multivariable prognostic models: issues in developing models, evaluating Assumptions and measuring and reducing errors. Statistics in Medicine. 1996;15:361–387
  8. Uretsky BF, Thygesen K, Armstrong PW, et al. Acute coronary findings at autopsy in heart failure patients with sudden death. Circulation. 2000;102:611–616
  9. Saxon LA, Bristow MR, Boehmer J, et al. Predictors of sudden cardiac death and appropriate shock in the Comparison of Medical Therapy, Pacing, and Defibrillation in Heart Failure (COMPANION) trial. Circulation. 2006;114:2766–2772
  10. Pitt B, Zannad F, Remme WJ, et al. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. N Engl J Med. 1999;341:709–717
  11. CIBIS-II Investigators . The cardiac insufficiency bisoprolol study II (CIBIS II): a randomized trial. Lancet. 1999;353:9–13
  12. Carson P, Anand I, O'Connor C, et al. Mode of death in advanced heart failure. J Am Coll Cardiol. 2005;46:2329–2334
  13. Yao G, Freemantle N, Calvert MJ, Bryan S, Daubert J-C, Cleland JGF. The long-term cost-effectiveness of cardiac resynchronization therapy with or without an implantable cardioverter-defibrillator. Eur Heart J. 2007;28:42–51

 Disclosures: Members of the Steering (J-CD, EE, NF, DG, LK, LT, JC) and Endpoints (KT, BFU) Committees received compensation for Cardiac Resynchronization in Heart Failure trial activities. Steering Committee members received speaking honoraria and research support. Data management and all statistical analyses were performed by sponsor-independent groups.

PII: S1071-9164(08)00176-0

doi: 10.1016/j.cardfail.2008.06.001

Journal of Cardiac Failure
Volume 14, Issue 8 , Pages 670-675 , October 2008

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