Journal of Cardiac Failure
Volume 14, Issue 6 , Pages 465-466 , August 2008

The Black Dog and the Weak Heart: Comorbid Depression in the Patient With Heart Failure

  • Henry Krum, MBBS, PhD, FRACP, FCSANZ

      Affiliations

    • Corresponding Author InformationReprint requests: Henry Krum, MBBS, PhD, FRACP, FCSANZ, Monash Centre of Cardiovascular Research and Education in Therapeutics, Department of Epidemiology and Preventive Medicine, Monash University/Alfred Hospital, 89 Commercial Road, Melbourne Vic 3004, Australia.
    • ,
  • Pupalan Iyngkaran, MBBS

References 

  1. Freedland KE, Rich MW, Skala JA, Carney RM, Dávila-Román VG, Jaffe AS. Prevalence of depression in hospitalized patients with congestive heart failure. Psychosom Med. 2003;65:119–128
  2. Jiang W, Kuchibhatla M, Clary GL, Cuffe MS, Christopher EJ, Alexander JD, et al. Relationship between depressive symptoms and long-term mortality in patients with heart failure. Am Heart J. 2007;154:102–108
  3. Rutledge T, Reis VA, Linke SE, Greenberg BH, Mills PJ. Depression in heart failure a meta-analytic review of prevalence, intervention effects, and associations with clinical outcomes. J Am Coll Cardiol. 2006;48:1527–1537
  4. Joynt KE, Whellan DJ, O'Connor CM. Why is depression bad for the failing heart? A review of the mechanistic relationship between depression and heart failure. J Card Fail. 2004;10:258–271
  5. Colucci WS. Molecular and cellular mechanisms of myocardial failure. Am J Cardiol. 1997;80(11A):15L–25L
  6. Angermann CE, Gelbrich G, Störk S, Fallgatter A, Deckert J, Faller H, et al. Rationale and design of a randomised, controlled, multicenter trial investigating the effects of selective serotonin re-uptake inhibition on morbidity, mortality and mood in depressed heart failure patients (MOOD-HF). Eur J Heart Fail. 2007;9:1212–1222
  7. Tousoulis D, Antoniades C, Drolias A, Stefanadi E, Marinou K, Vasiliadou C, et al. Selective serotonin reuptake inhibitors modify the effect of β-blockers on long-term survival of patients with end-stage heart failure and major depression. J Card Fail. 2008;14:456–464

PII: S1071-9164(08)00128-0

doi: 10.1016/j.cardfail.2008.04.003

Journal of Cardiac Failure
Volume 14, Issue 6 , Pages 465-466 , August 2008

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