Journal of Cardiac Failure
Volume 14, Issue 6 , Pages 456-464 , August 2008

Selective Serotonin Reuptake Inhibitors Modify the Effect of β-Blockers on Long-Term Survival of Patients With End-Stage Heart Failure and Major Depression

  • Dimitris Tousoulis, MD, PhD

      Affiliations

    • 1st Cardiology Department, Athens University Medical School, Athens, Greece
    • Corresponding Author InformationReprint requests: Dimitris Tousoulis, MD, PhD, FACC, Assistant Professor, 1st Cardiology Department University of Athens, Vasilissis Sofias 114, Ampelokipi 115 28, Athens, Greece.
    • ,
  • Charalambos Antoniades, MD

      Affiliations

    • 1st Cardiology Department, Athens University Medical School, Athens, Greece
    • ,
  • Apostolos Drolias, MD

      Affiliations

    • 1st Cardiology Department, Athens University Medical School, Athens, Greece
    • ,
  • Elli Stefanadi, MD

      Affiliations

    • 1st Cardiology Department, Athens University Medical School, Athens, Greece
    • ,
  • Kyriakoyla Marinou, MD

      Affiliations

    • 1st Cardiology Department, Athens University Medical School, Athens, Greece
    • ,
  • Carmen Vasiliadou, MSc

      Affiliations

    • 1st Cardiology Department, Athens University Medical School, Athens, Greece
    • ,
  • Costas Tsioufis, MD

      Affiliations

    • 1st Cardiology Department, Athens University Medical School, Athens, Greece
    • ,
  • Kostas Toutouzas, MD

      Affiliations

    • 1st Cardiology Department, Athens University Medical School, Athens, Greece
    • ,
  • George Latsios, MD

      Affiliations

    • 1st Cardiology Department, Athens University Medical School, Athens, Greece
    • ,
  • Christodoulos Stefanadis, MD, FACC, FESC

      Affiliations

    • 1st Cardiology Department, Athens University Medical School, Athens, Greece

Received 12 November 2007 ,Revised 23 February 2008 ,Accepted 25 February 2008.

References 

  1. Carney RM, Blumenthal JA, Stein PK, Watkins L, Catellier D, Berkman LF, et al. Depression, heart rate variability, and acute myocardial infarction. Circulation. 2001;104:2024–2028
  2. Otte C, Neylan TC, Pipkin SS, Browner WS, Whooley MA. Depressive symptoms and 24-hour urinary norepinephrine excretion levels in patients with coronary disease: findings from the Heart and Soul Study. Am J Psychiatry. 2005;162:2139–2145
  3. Empana JP, Sykes DH, Luc G, Juhan-Vague I, Arveiler D, Ferrieres J, et al. Contributions of depressive mood and circulating inflammatory markers to coronary heart disease in healthy European men: the Prospective Epidemiological Study of Myocardial Infarction (PRIME). Circulation. 2005;111:2299–2305
  4. Tentolouris C, Tousoulis D, Antoniades C, Bosinakou E, Kotsopoulou M, Trikas A, et al. Endothelial function and proinflammatory cytokines in patients with ischemic heart disease and dilated cardiomyopathy. Int J Cardiol. 2004;94:301
  5. Ferketich AK, Ferguson JP, Binkley PF. Depressive symptoms and inflammation among heart failure patients. Am Heart J. 2005;150:132–136
  6. Rutledge T, Reis VA, Linke SE, Greenberg BH, Mills PJ. Depression in heart failure a meta-analytic review of prevalence, intervention effects, and associations with clinical outcomes. J Am Coll Cardiol. 2006;48:1527–1537
  7. Merit-HF Study Group . Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL Randomised Intervention Trial in-Congestive Heart Failure (MERIT-HF). Lancet. 1999;353:2001
  8. Cibis-Ii Investigators . The Cardiac Insufficiency Bisoprolol Study II (CIBIS-II): a randomised trial. Lancet. 1999;353:9
  9. Packer M, Bristow MR, Cohn JN, Colucci WS, Fowler MB, Gilbert EM, et al. The USCHFSG. The effect of carvedilol on morbidity and mortality in patients with chronic heart failure. N Engl J Med. 1996;334:1349–1355
  10. Packer M, Coats AJS, Fowler MB, Katus HA, Krum H, Mohacsi P, et al. the Carvedilol Prospective Randomized Cumulative Survival Study Group Effect of carvedilol on survival in severe chronic heart failure. N Engl J Med. 2001;344:1651–1658
  11. Packer M, Fowler MB, Roecker EB, Coats AJ, Katus HA, Krum H, et al. Effect of carvedilol on the morbidity of patients with severe chronic heart failure: results of the carvedilol prospective randomized cumulative survival (COPERNICUS) study. Circulation. 2002;106:2194–2199
  12. The Beta-Blocker Evaluation of Survival Trial I. A trial of the beta-blocker bucindolol in patients with advanced chronic heart failure. N Engl J Med. 2001;344:1659–1667
  13. Pacher P, Ungvari Z, Kecskemeti V, Furst S. Review of cardiovascular effects of fluoxetine, a selective serotonin reuptake inhibitor, compared to tricyclic antidepressants. Curr Med Chem. 1998;5:381–390
  14. Roose SP. Depression, anxiety, and the cardiovascular system: the psychiatrist's perspective. J Clin Psychiatry. 2001;62(Suppl 8):19–23
  15. Lorig K, Gonzalez V, Laurent D. The chronic disease self-management course leader's manual. Stanford (CA): Stanford University; 1997;
  16. Jiang W, Glassman A, Krishnan R, O'Connor CM, Califf RM. Depression and ischemic heart disease: what have we learned so far and what must we do in the future?. Am Heart J. 2005;150:54–78
  17. Finkel MS, Oddis CV, Jacob TD, Watkins SC, Hattler BG, Simmons RL. Negative inotropic effects of cytokines on the heart mediated by nitric oxide. Science. 1992;257:387–389
  18. Blum A, Miller H. Pathophysiological role of cytokines in congestive heart failure. Annu Rev Med. 2001;52:15–27
  19. Pasic J, Levy WC, Sullivan MD. Cytokines in depression and heart failure. Psychosom Med. 2003;65:181–193
  20. Tousoulis D, Antoniades C, Koumallos N, Stefanadis C. Pro-inflammatory cytokines in acute coronary syndromes: from bench to bedside. Cytokine Growth Factor Rev. 2006;17:225–233
  21. Miller GE, Stetler CA, Carney RM, Freedland KE, Banks WA. Clinical depression and inflammatory risk markers for coronary heart disease. Am J Cardiol. 2002;90:1279–1283
  22. Suarez EC, Krishnan RR, Lewis JG. The relation of severity of depressive symptoms to monocyte-associated proinflammatory cytokines and chemokines in apparently healthy men. Psychosom Med. 2003;6:362–368
  23. Tsutamoto T, Hisanaga T, Wada A, Maeda K, Ohnishi M, Fukai D, et al. Interleukin-6 spillover in the peripheral circulation increases with the severity of heart failure, and the high plasma level of interleukin-6 is an important prognostic predictor in patients with congestive heart failure. J Am Coll Cardiol. 1998;31:391–398
  24. Drolias A, Tousoulis D, Antoniades C, Tentolouris C, Vasiliadou C, Trikas A, et al. Non-selective serotonin reuptake inhibitors modify inflammatory process in patients with heart failure and depression. Eur Heart J. 2006;27(abstract supplement):230
  25. Bayram M, De Luca L, Massie MB, Gheorghiade M. Reassessment of dobutamine, dopamine, and milrinone in the management of acute heart failure syndromes. Am J Cardiol. 2005;96(Suppl 1):47
  26. Shannon R, Chaudhry M. Effect of alpha1-adrenergic receptors in cardiac pathophysiology. Am Heart J. 2006;152:842–850
  27. McMurray J, Cohen-Solal A, Dietz R, Eichhorn E, Erhardt L, Hobbs FDR, et al. Practical recommendations for the use of ACE inhibitors, beta-blockers, aldosterone antagonists and angiotensin receptor blockers in heart failure: putting guidelines into practice. Eur J Heart Failure. 2005;7:710
  28. Mann JJ. The medical management of depression. N Engl J Med. 2005;353:1819–1834
  29. Magyar J, Rusznak Z, Harasztosi C, Kortvely A, Pacher P, Banyasz T, et al. Differential effects of fluoxetine enantiomers in mammalian neural and cardiac tissues. Int J Mol Med. 2003;11:535–542
  30. Qvigstad E, Brattelid T, Sjaastad I, Andressen KW, Krobert KA, Birkeland JA, et al. Appearance of a ventricular 5-HT4 receptor-mediated inotropic response to serotonin in heart failure. Cardiovasc Res. 2005;65:869–878
  31. Qvigstad E, Sjaastad I, Brattelid T, Nunn C, Swift F, Birkeland JAK, et al. Dual serotonergic regulation of ventricular contractile force through 5-HT2A and 5-HT4 receptors induced in the acute failing heart. Circ Res. 2005;97:268–276
  32. Cohen MD, Finberg J, Dibner-Dunlap M, Yuih SN, Thames MD. Effects of desipramine hydrochloride on peripheral sympathetic nerve activity. Am J Physiol. 1990;258:R876–R882
  33. Ohtani H, Odagiri Y, Sato H, Sawada Y, Iga T. A comparative pharmacodynamic study of the arrhythmogenicity of antidepressants, fluvoxamine and imipramine, in guinea pigs. Biol Pharm Bull. 2001;24:550–554

PII: S1071-9164(08)00082-1

doi: 10.1016/j.cardfail.2008.02.015

Journal of Cardiac Failure
Volume 14, Issue 6 , Pages 456-464 , August 2008

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