Journal of Cardiac Failure
Volume 14, Issue 6 , Pages 489-496 , August 2008

Decreasing Body Temperature Predicts Early Rehospitalization in Congestive Heart Failure

  • Amany Ahmed, MD

      Affiliations

    • Texas Heart Institute at St Luke's Episcopal Hospital, Houston, Texas
    • University of Texas Health Sciences Center, Houston, Texas
    • Corresponding Author InformationReprint requests: Amany Ahmed, MD, Texas Heart Institute, 6770 Bertner Avenue, MC 2-255, Houston, TX 77030.
    • ,
  • Ibrahim Aboshady, MD

      Affiliations

    • Texas Heart Institute at St Luke's Episcopal Hospital, Houston, Texas
    • University of Texas Health Sciences Center, Houston, Texas
    • ,
  • Shahzeb M. Munir, MD

      Affiliations

    • Texas Heart Institute at St Luke's Episcopal Hospital, Houston, Texas
    • University of Texas Health Sciences Center, Houston, Texas
    • ,
  • Sreedevi Gondi, MD

      Affiliations

    • Texas Heart Institute at St Luke's Episcopal Hospital, Houston, Texas
    • University of Texas Health Sciences Center, Houston, Texas
    • ,
  • Alan Brewer, MBA

      Affiliations

    • Texas Heart Institute at St Luke's Episcopal Hospital, Houston, Texas
    • ,
  • S. David Gertz, MD, PhD

      Affiliations

    • Hebrew University, Hadassah Medical School, Jerusalem, Israel
    • ,
  • Dejian Lai, PhD

      Affiliations

    • University of Texas, School of Public Health, Houston, Texas
    • ,
  • Naushad A. Shaik, MD

      Affiliations

    • Emory University, Atlanta, Georgia
    • ,
  • K.J. Shankar, MD

      Affiliations

    • Texas Heart Institute at St Luke's Episcopal Hospital, Houston, Texas
    • University of Texas Health Sciences Center, Houston, Texas
    • ,
  • Anita Deswal, MD, MPH

      Affiliations

    • Michael E. DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas
    • ,
  • S. Ward Casscells, MD

      Affiliations

    • Texas Heart Institute at St Luke's Episcopal Hospital, Houston, Texas
    • University of Texas Health Sciences Center, Houston, Texas

Received 23 July 2007 ,Revised 7 February 2008 ,Accepted 12 February 2008.

References 

  1. American Heart Association. Heart Disease and Stroke Statistics–2005 Update. Dallas, TX: American Heart Association; 2005;Available at: www.americanheart.org/downloadable/heart/1105390918119HDSStats2005Update.#pdfAccessed September 13, 2006
  2. Vranckx P, Van Cleemput J. Prognostic assessment of end-stage cardiac failure. Acta Cardiol. 1998;53:121–125
  3. Casscells W, Vasseghi MF, Siadaty MS, Madjid M, Siddiqui H, Lal B, et al. Hypothermia is a bedside predictor of imminent death in patients with congestive heart failure. Am Heart J. 2005;149:927–933
  4. Ahmed A, Payvar S, Aboshady I, Munir MS, Eftekhari H, Shaik N, et al. Low body temperature at hospital discharge is a marker of poor prognosis in patients with congestive heart failure. J Am Coll Cardiol. 2006;47:88A
  5. Senni M, Tribouilloy CM, Rodeheffer RJ, Jacobsen SJ, Evans JM, Bailey KR, et al. Congestive heart failure in the community: a study of all incident cases in Olmsted County, Minnesota, in 1991. Circulation. 1998;98:2282–2289
  6. Hooper VD, Andrews JO. Accuracy of noninvasive core temperature measurement in acutely ill adults: the state of science. Biol Res Nurs. 2006;8:24–34
  7. Homser DW, Stanley L. Applied logistic regression. New York: Wiley; 1989;25
  8. Homser DW, Stanley L. Regression models for survival time. In: Applied Survival Analysis: Regression Modeling of Time to Event Data. New York: Wiley; 1999;90
  9. Lee TT, Chen J, Cohen DJ, Tsao L. The association between blood pressure and mortality in patients with heart failure. Am Heart J. 2006;151:76–83
  10. Siddiqui H, Patel S, Lal B, Naghavi M, Casscells SW. Hypothermia: a new indicator of imminent death in congestive heart failure. J Am Coll Cardiol. 1999;33:212A
  11. Nallamothu BK, Payvar S, Wang Y, Kosiborod M, Masoudi FA, Havranek EP, et al. Admission body temperature and mortality in elderly patients hospitalized for heart failure. J Am Coll Cardiol. 2006;47:2563–2564
  12. Boulay F, Berthier F, Sisteron O, Gendreike Y, Gibelin P. Seasonal variation in chronic heart failure hospitalizations and mortality in France. Circulation. 1999;100:280–286
  13. Stewart S, McIntyre K, Capewell S, McMurray JJ. Heart failure in a cold climate. Seasonal variation in heart failure-related morbidity and mortality. J Am Coll Cardiol. 2002;39:760–766
  14. Feldman DE, Platt R, Dery V, Kapetanakis C, Lamontagne D, Ducharme A, et al. Seasonal congestive heart failure mortality and hospitalization trends, Quebec 1990–1998. J Epidemiol Community Health. 2004;58:129–130
  15. Blanchet M, Ducharme A, Racine N, Normand A, Curnier D, Tardif JC, et al. Effects of cold exposure on submaximal exercise performance and adrenergic activation in patients with congestive heart failure and the effects of beta-adrenergic blockade (carvedilol or metoprolol). Am J Cardiol. 2003;92:548–553
  16. Cohn JN, Levine TB, Olivari MT, Garberg V, Lura D, Francis GS, et al. Plasma norepinephrine as a guide to prognosis in patients with chronic congestive heart failure. N Engl J Med. 1984;311:819–823
  17. Park SM, Shim WJ, Ahn JC, Lim DS, Kim YH, Ro YM. Changes of coronary blood flow in vasospastic angina under cold stimulation by transthoracic Doppler echocardiography. J Korean Med Sci. 2005;20:204–208
  18. Danzl D. Hypothermia. Semin Respir Crit Care Med. 2002;23:57–68
  19. Shellock FG, Rubin SA, Ellrodt AG, Muchlinski A, Brown H, Swan HJ. Unusual core temperature decrease in exercising heart-failure patients. J Appl Physiol. 1983;54:544–550
  20. Cui J, Arbab-Zadeh A, Prasad A, Durand S, Levine BD, Crandall CG. Effects of heat stress on thermoregulatory responses in congestive heart failure patients. Circulation. 2005;112:2286–2292
  21. Nguyen Y, Naseer N, Frishman WH. Sauna as a therapeutic option for cardiovascular disease. Cardiol Rev. 2004;12:321–324
  22. Tei C, Horikiri Y, Park JC, Jeong JW, Chang KS, Toyama Y, et al. Acute hemodynamic improvement by thermal vasodilation in congestive heart failure. Circulation. 1995;91:2582–2590
  23. Kihara T, Biro S, Ikeda Y, Fukudome T, Shinsato T, Masuda A, et al. Effects of repeated sauna treatment on ventricular arrhythmias in patients with chronic heart failure. Circ J. 2004;68:1146–1151
  24. Shafi S, Elliott AC, Gentilello L. Is hypothermia simply a marker of shock and injury severity or an independent risk factor for mortality in trauma patients? Analysis of a large national trauma registry. J Trauma. 2005;59:1081–1085
  25. Martin RS, Kilgo PD, Miller PR, Hoth JJ, Meredith JW, Chang MC. Injury-associated hypothermia: an analysis of the 2004 National Trauma Data Bank. Shock. 2005;24:114–118
  26. Jurkovich GJ, Greiser WB, Luterman A, Curreri PW. Hypothermia in trauma victims: an ominous predictor of survival. J Trauma. 1987;27:1019–1024
  27. Fakhry SM, Michetti CP. Bleeding and coagulation complications. In:  Moore EE,  Feliciano VD,  Mattox KL editor. Trauma. 5th edition. New York: McGraw-Hill; 2004;p. 1256–1257
  28. Knappe T, Mittlemeier T, Eipel C, Amon M, Menger MD, Vollmar B. Effect of systemic hypothermia on local soft tissue trauma-induced microcirculatory and cellular dysfunction in mice. Crit Care Med. 2005;33:1805–1813
  29. Remick DG, Xioa H. Hypothermia and sepsis. Front Biosci. 2006;11:1006–1013
  30. Xioa H, Remick DG. Correction of perioperative hypothermia decreases experimental sepsis mortality by modulating the inflammatory response. Crit Care Med. 2005;33:161–167
  31. Luna GK, Maier RV, Pavlin EG, Anardi D, Copass MK, Oreskovich MR. Incidence and effect of hypothermia in seriously injured patients. J Trauma. 1987;27:1014–1018
  32. McKinley MJ, Albiston AL, Allen AM, Mathai ML, May CN, McAllen RM, et al. The brain renin-angiotensin system: location and physiological roles. Int J Biochem Cell Biol. 2003;35:901–918
  33. Watanabe T, Miyoshi M, Imoto T. Angiotensin II: its effects on fever and hypothermia in systemic inflammation. Front Biosci. 2004;9:438–447
  34. Leite LH, Lacerda AC, Marubayashi U, Coimbra CC. Central angiotensin AT1-receptor blockade affects thermoregulation and running performance in rats. Am J Physiol Regul Integr Comp Physiol. 2006;291:R603–R607
  35. Juneau M, Larivee L, White M. Cold temperature impairs maximal exercise performance in patients with heart failure: attenuated by acute ACE inhibitor therapy. Can J Cardiol. 2002;18:981–986
  36. Jansky L, Vybiral S, Pospisilova D, Roth J, Dornand J, Zeisberger E, et al. Production of systemic and hypothalamic cytokines during the early phase of endotoxin fever. Neuroendocrinology. 1995;62:55–61
  37. Palmieri EA, Benincasa G, Di Rella F, Casaburi C, Monti MG, De Simone G, et al. Differential expression of TNF-alpha, IL-6, and IGF-1 by graded mechanical stress in normal rat myocardium. Am J Physiol Heart Circ Physiol. 2002;282:H926–H934
  38. Baumgarten G, Knuefermann P, Kalra D, Gao F, Taffet GE, Michael L, et al. Load-dependent and -independent regulation of proinflammatory cytokine and cytokine receptor gene expression in the adult mammalian heart. Circulation. 2002;105:2192–2197
  39. Toth MJ, Poehlman ET. Energetic adaptation to chronic disease in the elderly. Nutr Rev. 2000;58:61–66
  40. Shellock FG, Rubin SA. Mixed venous blood temperature response to exercise in heart failure patients treated with short-term vasodilators. Clin Physiol. 1985;5:503–514
  41. Toth MJ, Gottlieb SS, Goran MI, Fisher ML, Poehlman ET. Daily energy expenditure in free-living heart failure patients. Am J Physiol. 1997;272:E469–E475
  42. Westheim A, Os I, Thaulow E, Kjeldsen SE, Eritsland J, Eide IK. Haemodynamic and neurohumoral effects of cold pressor test in severe heart failure. Clin Physiol. 1992;12:95–106
  43. Rodriguez-Garcia JL, Paule A, Dominguez J, Garcia-Escribano JR, Vazquez M. Effects of the angiotensin II antagonist losartan on endothelin-1 and norepinephrine plasma levels during cold pressor test in patients with chronic heart failure. Int J Cardiol. 1999;70:293–301

PII: S1071-9164(08)00067-5

doi: 10.1016/j.cardfail.2008.02.008

Journal of Cardiac Failure
Volume 14, Issue 6 , Pages 489-496 , August 2008

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