Journal of Cardiac Failure
Volume 14, Issue 5 , Pages 426-430 , June 2008

Activation of Ecto-5′-Nucleotidase in the Blood and Hearts of Patients With Chronic Heart Failure

  • Masashi Fujita, MD, PhD

      Affiliations

    • Departments of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    • ,
  • Masanori Asakura, MD, PhD

      Affiliations

    • Cardiovascular Division of Medicine, National Cardiovascular Center, Suita, Japan
    • ,
  • Shoji Sanada, MD, PhD

      Affiliations

    • Division of Cardiology, Osaka General Medical Center, Osaka, Japan
    • ,
  • Hiroharu Funaya, MD, PhD

      Affiliations

    • Departments of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    • ,
  • Osamu Tsukamoto, MD, PhD

      Affiliations

    • Departments of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    • ,
  • Kazuo Komamura, MD, PhD

      Affiliations

    • Cardiovascular Division of Medicine, National Cardiovascular Center, Suita, Japan
    • ,
  • Hiroshi Asanuma, MD, PhD

      Affiliations

    • Cardiovascular Division of Medicine, National Cardiovascular Center, Suita, Japan
    • ,
  • Satoshi Taketani, MD, PhD

      Affiliations

    • Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Suita, Japan
    • ,
  • Tadashi Isomura, MD, PhD

      Affiliations

    • Hayama Heart Center, Hayama, Japan
    • ,
  • Kenji Nakamaru, PhD

      Affiliations

    • Biomedical Research Laboratories, Sankyo Co. Ltd, Tokyo, Japan
    • ,
  • Hidehiko Furukawa, PhD

      Affiliations

    • Biomedical Research Laboratories, Sankyo Co. Ltd, Tokyo, Japan
    • ,
  • Yoshiki Sawa, MD, PhD

      Affiliations

    • Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Suita, Japan
    • ,
  • Masatsugu Hori, MD, PhD

      Affiliations

    • Departments of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    • ,
  • Masafumi Kitakaze, MD, PhD

      Affiliations

    • Cardiovascular Division of Medicine, National Cardiovascular Center, Suita, Japan
    • Corresponding Author InformationReprint requests: Masafumi Kitakaze, MD, PhD, Director, Cardiovascular Division of Medicine, National Cardiovascular Center, 5-7-1 Fujishiro-dai, Suita, Osaka, 565-8565, Japan.

Received 19 July 2007 ,Revised 23 January 2008 ,Accepted 28 January 2008.

References 

  1. Hori M, Kitakaze M. Adenosine, the heart, and coronary circulation. Hypertension. 1991;18:565–574
  2. Berne RM. The role of adenosine in the regulation of coronary blood flow. Circ Res. 1980;47:807–813
  3. Kitakaze M, Node K, Komamura K, Minamino T, Kosaka H, Kuzuya T, et al. Intracoronary administration of adenosine triphosphate increases coronary blood flow and attenuates the severity of myocardial ischemic injury in dogs. Cardiovasc Drugs Ther. 1999;13:407–414
  4. Minamino T, Kitakaze M, Asanuma H, Tomiyama Y, Shiraga M, Sato H, et al. Endogenous adenosine inhibits P-selectin-dependent formation of coronary thromboemboli during hypoperfusion in dogs. J Clin Invest. 1998;101:1643–1653
  5. Funaya H, Kitakaze M, Node K, Minamino T, Komamura K, Hori M. Plasma adenosine levels increase in patients with chronic heart failure. Circulation. 1997;95:1363–1365
  6. Kitakaze M, Hori M, Morioka T, Minamino T, Takashima S, Okazaki Y, et al. Alpha 1-adrenoceptor activation increases ecto-5'-nucleotidase activity and adenosine release in rat cardiomyocytes by activating protein kinase C. Circulation. 1995;91:2226–2234
  7. Savic V, Stefanovic V, Ardaillou N, Ardaillou R. Induction of ecto-5'-nucleotidase of rat cultured mesangial cells by interleukin-1 beta and tumour necrosis factor-alpha. Immunology. 1990;70:321–326
  8. Yamane R, Nakamura T, Matsuura E, Ishige H, Fujimoto M. A simple and sensitive radioimmunoassay for adenosine. J Immunoassay. 1991;12:501–519
  9. Node K, Kitakaze M, Minamino T, Tada M, Inoue M, Hori M, et al. Activation of ecto-5'-nucleotidase by protein kinase C and its role in ischaemic tolerance in the canine heart. Br J Pharmacol. 1997;120:273–281
  10. Smith K, Varon HH, Race GJ, Paulson DL, Urschel HC, Mallams JT. Serum 5'-nucleotidase in patients with tumor in the liver. Cancer. 1966;19:1281–1285
  11. Vatner DE, Asai K, Iwase M, Ishikawa Y, Shannon RP, Homcy CJ, et al. Beta-adrenergic receptor-G protein-adenylyl cyclase signal transduction in the failing heart. Am J Cardiol. 1999;83:80H–85H
  12. Mehra MR, Uber PA, Potluri S. Renin angiotensin aldosterone and adrenergic modulation in chronic heart failure: contemporary concepts. Am J Med Sci. 2002;324:267–275
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  14. Shen W, Asai K, Uechi M, Mathier MA, Shannon RP, Vatner SF, et al. Progressive loss of myocardial ATP due to a loss of total purines during the development of heart failure in dogs: a compensatory role for the parallel loss of creatine. Circulation. 1999;100:2113–2118
  15. Zhang J, Wilke N, Wang Y, Zhang Y, Wang C, Eijgelshoven MH, et al. Functional and bioenergetic consequences of postinfarction left ventricular remodeling in a new porcine model. MRI and 31 P-MRS study. Circulation. 1996;94:1089–1100
  16. Parmely MJ, Zhou WW, Edwards CK, Borcherding DR, Silverstein R, Morrison DC. Adenosine and a related carbocyclic nucleoside analogue selectively inhibit tumor necrosis factor-alpha production and protect mice against endotoxin challenge. J Immunol. 1993;151:389–396
  17. Kalsi KK, Yuen AH, Rybakowska IM, Johnson PH, Slominska E, Birks EJ, et al. Decreased cardiac activity of AMP deaminase in subjects with the AMPD1 mutation—a potential mechanism of protection in heart failure. Cardiovasc Res. 2003;59:678–684
  18. Kitakaze M, Minamino T, Node K, Koretsune Y, Komamura K, Funaya H, et al. Elevation of plasma adenosine levels may attenuate the severity of chronic heart failure. Cardiovasc Drugs Ther. 1998;12:307–309
  19. Loh E, Rebbeck TR, Mahoney PD, DeNofrio D, Swain JL, Holmes EW. Common variant in AMPD1 gene predicts improved clinical outcome in patients with heart failure. Circulation. 1999;99:1422–1425
  20. Asakura M, Asanuma H, Kim J, Liao Y, Nakamaru K, Fujita M, et al. Impact of adenosine receptor signaling and metabolism on pathophysiology in patients with chronic heart failure. Hypertens Res. 2007;30:781–787

 Supported by a Grant from Japan Cardiovascular Research Foundation and also supported by either grants-in-aid for Human Genome, Tissue Engineering and Food Biotechnology (H13-Genome-011), or grants on Comprehensive Research on Aging and Health (H13-21seiki(seikatsu)-23) in Health and Labour Sciences Research Grants Research from Ministry of Health and Labour and Welfare, Japan. Dr. Tsukamoto is a Research Fellow of Japan Society for the Promotion of Science for Young Scientist.

PII: S1071-9164(08)00039-0

doi: 10.1016/j.cardfail.2008.01.011

Journal of Cardiac Failure
Volume 14, Issue 5 , Pages 426-430 , June 2008

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