Journal of Cardiac Failure
Volume 14, Issue 5 , Pages 394-399 , June 2008

Impact of Myocardial Function on Cystatin C Measurements in Chronic Systolic Heart Failure

  • W.H. Wilson Tang, MD

      Affiliations

    • Kaufman Center for Heart Failure, Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland Ohio
    • Corresponding Author InformationReprint requests: W. H. Wilson Tang, MD, Section of Heart Failure and Cardiac Transplantation Medicine, Department of Cardiovascular Medicine, Cleveland Clinic, 9500 Euclid Avenue, Desk F25, Cleveland, OH 44195.
    • ,
  • Frederick Van Lente, PhD

      Affiliations

    • Department of Clinical Pathology, Cleveland Clinic, Cleveland Ohio
    • ,
  • Kevin Shrestha

      Affiliations

    • Kaufman Center for Heart Failure, Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland Ohio
    • ,
  • Richard W. Troughton, MB, ChB

      Affiliations

    • Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand
    • ,
  • Gary S. Francis, MD

      Affiliations

    • Kaufman Center for Heart Failure, Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland Ohio
    • ,
  • Wilson Tong, MSc

      Affiliations

    • Kaufman Center for Heart Failure, Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland Ohio
    • ,
  • Maureen G. Martin, RDCS

      Affiliations

    • Kaufman Center for Heart Failure, Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland Ohio
    • ,
  • Allen G. Borowski, RDCS

      Affiliations

    • Kaufman Center for Heart Failure, Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland Ohio
    • ,
  • Sue Jasper, RN, BSN

      Affiliations

    • Kaufman Center for Heart Failure, Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland Ohio
    • ,
  • Randall C. Starling, MD, MPH

      Affiliations

    • Kaufman Center for Heart Failure, Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland Ohio
    • ,
  • Allan L. Klein, MD

      Affiliations

    • Kaufman Center for Heart Failure, Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland Ohio

Received 19 September 2007 ,Revised 21 November 2007 ,Accepted 11 January 2008.

References 

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  3. McAlister FA, Ezekowitz J, Tonelli M, Armstrong PW. Renal insufficiency and heart failure: prognostic and therapeutic implications from a prospective cohort study. Circulation. 2004;109:1004–1009
  4. Newman DJ. Cystatin C. Ann Clin Biochem. 2002;39(Pt 2):89–104
  5. Grubb A, Bjork J, Lindstrom V, Sterner G, Bondesson P, Nyman U. A cystatin C-based formula without anthropometric variables estimates glomerular filtration rate better than creatinine clearance using the Cockcroft-Gault formula. Scand J Clin Lab Invest. 2005;65:153–162
  6. Newman DJ, Thakkar H, Edwards RG, Wilkie M, White T, Grubb AO, et al. Serum cystatin C measured by automated immunoassay: a more sensitive marker of changes in GFR than serum creatinine. Kidney Int. 1995;47:312–318
  7. Laterza OF, Price CP, Scott MG. Cystatin C: an improved estimator of glomerular filtration rate?. Clin Chem. 2002;48:699–707
  8. Codognotto M, Piccoli A, Zaninotto M, Mion M, Vertolli U, Tona F, et al. Cystatin C in heart failure is nothing more than a bystander of glomerular filtration. J Nephrol. 2007;20:219–227
  9. Lassus J, Harjola VP, Sund R, Siirila-Waris K, Melin J, Peuhkurinen K, et al. Prognostic value of cystatin C in acute heart failure in relation to other markers of renal function and NT-proBNP. Eur Heart J. 2007;28:1841–1847
  10. Arimoto T, Takeishi Y, Niizeki T, Takabatake N, Okuyama H, Fukui A, et al. Cystatin C, a novel measure of renal function, is an independent predictor of cardiac events in patients with heart failure. J Card Fail. 2005;11:595–601
  11. Sarnak MJ, Katz R, Stehman-Breen CO, Fried LF, Jenny NS, Psaty BM, et al. Cystatin C concentration as a risk factor for heart failure in older adults. Ann Intern Med. 2005;142:497–505
  12. Ix JH, Shlipak MG, Chertow GM, Whooley MA. Association of cystatin C with mortality, cardiovascular events, and incident heart failure among persons with coronary heart disease: data from the Heart and Soul Study. Circulation. 2007;115:173–179
  13. Ix JH, Shlipak MG, Chertow GM, Ali S, Schiller NB, Whooley MA. Cystatin C, left ventricular hypertrophy, and diastolic dysfunction: data from the Heart and Soul Study. J Card Fail. 2006;12:601–607
  14. Troughton RW, Prior DL, Pereira JJ, Martin M, Fogarty A, Morehead A, et al. Plasma B-type natriuretic peptide levels in systolic heart failure: importance of left ventricular diastolic function and right ventricular systolic function. J Am Coll Cardiol. 2004;43:416–422
  15. Erlandsen EJ, Randers E, Kristensen JH. Evaluation of the Dade Behring N Latex Cystatin C assay on the Dade Behring Nephelometer II System. Scand J Clin Lab Invest. 1999;59:1–8
  16. Drazner MH, Rame JE, Dries DL. Third heart sound and elevated jugular venous pressure as markers of the subsequent development of heart failure in patients with asymptomatic left ventricular dysfunction. Am J Med. 2003;114:431–437
  17. Lucas C, Johnson W, Hamilton MA, Fonarow GC, Woo MA, Flavell CM, et al. Freedom from congestion predicts good survival despite previous class IV symptoms of heart failure. Am Heart J. 2000;140:840–847
  18. Firth JD, Raine AE, Ledingham JG. Raised venous pressure: a direct cause of renal sodium retention in oedema?. Lancet. 1988;1:1033–1035
  19. Winton F. The influence of venous pressure on the isolated mammalian kidney. J Physiol. 1931;72:49–61
  20. Damman K, Navis G, Smilde TD, Voors AA, van der Bij W, van Veldhuisen DJ, et al. Decreased cardiac output, venous congestion and the association with renal impairment in patients with cardiac dysfunction. Eur J Heart Fail. 2007;9:872–878
  21. Shlipak MG, Katz R, Fried LF, Jenny NS, Stehman-Breen CO, Newman AB, et al. Cystatin-C and mortality in elderly persons with heart failure. J Am Coll Cardiol. 2005;45:268–271

 The main study (Assessment of Doppler Echocardiography in Prognosis and Therapy study) was partially supported by research grants from the American Society of Echocardiography, GlaxoSmithKline Pharmaceuticals, and Roche Diagnostics Inc.

PII: S1071-9164(08)00024-9

doi: 10.1016/j.cardfail.2008.01.006

Journal of Cardiac Failure
Volume 14, Issue 5 , Pages 394-399 , June 2008

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