Journal of Cardiac Failure
Volume 14, Issue 4 , Pages 303-309 , May 2008

Inpatient Initiation of β-blockade Plus Nurse Management in Vulnerable Heart Failure Patients: A Randomized Study

  • Mori J. Krantz, MD

      Affiliations

    • Department of Medicine, Cardiology Division at Denver Health Medical Center and the University of Colorado Health Sciences Center
    • Colorado Prevention Center, Denver, Colorado
    • Corresponding Author InformationReprint requests: Mori J. Krantz, MD, Denver Health Medical Center, Mail Code 0960, 777 Bannock Street, Denver CO 80204-4507.
    • ,
  • Edward P. Havranek, MD

      Affiliations

    • Department of Medicine, Cardiology Division at Denver Health Medical Center and the University of Colorado Health Sciences Center
    • Colorado Prevention Center, Denver, Colorado
    • ,
  • Deborah K. Haynes, RN BScN

      Affiliations

    • Department of Medicine, Cardiology Division at Denver Health Medical Center and the University of Colorado Health Sciences Center
    • Colorado Prevention Center, Denver, Colorado
    • ,
  • Inez Smith, RN, BAN

      Affiliations

    • Department of Medicine, Cardiology Division at Denver Health Medical Center and the University of Colorado Health Sciences Center
    • Colorado Prevention Center, Denver, Colorado
    • ,
  • Becki Bucher-Bartelson, PhD

      Affiliations

    • Colorado Prevention Center, Denver, Colorado
    • ,
  • Carlin S. Long, MD

      Affiliations

    • Department of Medicine, Cardiology Division at Denver Health Medical Center and the University of Colorado Health Sciences Center
    • Colorado Prevention Center, Denver, Colorado

Received 26 November 2007 ,Revised 17 December 2007 ,Accepted 18 December 2007.

References 

  1. American Heart Association. Heart disease and stroke statistics: 2005 update. Dallas, TX: American Heart Association; 2005;
  2. Deswal A, Petersen N, Urbauer D, Wright S, Beyth R. Racial variations in quality of care and outcomes in an ambulatory heart failure cohort. Am Heart J. 2006;152:348–354
  3. Khand A, Gemmel I, Clark AL, Cleland JG. Is the prognosis of heart failure improving?. J Am Coll Cardiol. 2000;36:2284–2286
  4. JCAHO overview of heart failure core measure set. Available at: http://www.jointcommission.org/PerformanceMeasurement/PerformanceMeasurement/Heart+Failure+Core+Measure+Set.htm. Accessed December 29, 2006.
  5. Lindenauer PK, Remus D, Roman S, Rothberg MB, Benjamin EM, Ma A, et al. Public reporting and pay for performance in hospital quality improvement. N Engl J Med. 2007;356:486–496
  6. Rowe JW. Pay-for-performance and accountability: related themes in improving health care. Ann Intern Med. 2006;145:695–699
  7. Brophy JM, Joseph L, Rouleau JL. Beta-blockers in congestive heart failure. A Bayesian meta-analysis. Ann Intern Med. 2001;134:550–560
  8. Masoudi FA, Rathore SS, Wang Y, Havranek EP, Curtis JP, Foody JM, et al. National patterns of use and effectiveness of angiotensin-converting enzyme inhibitors in older patients with heart failure and left ventricular systolic dysfunction. Circulation. 2004;110:724–731
  9. Fonarow GC, Yancy CW, Heywood JT, ADHERE Scientific Advisory Committee , Study Group, and Investigators . Adherence to heart failure quality-of-care indicators in US hospitals: analysis of the ADHERE Registry. Arch Intern Med. 2005;165:1469–1477
  10. Butler J, Arbogast PG, BeLue R, Daugherty J, Jain MK, Ray WA, et al. Outpatient adherence to beta-blocker therapy after acute myocardial infarction. J Am Coll Cardiol. 2002;40:1589–1595
  11. Heart Failure Society of America Guideline Committee. HFSA guidelines for the management of patients with heart failure caused by left ventricular systolic dysfunction: pharmacologic approaches. J Card Fail. 1999;5:357–382
  12. Gattis WA, O'Connor CM, Gallup DS, Hasselblad V, Gheorghiade M. Pre-discharge initiation of carvedilol in patients hospitalized with decompensated heart failure. J Am Coll Cardiol. 2004;43:1534–1541
  13. Fonarow GC, Abraham WT, Albert NM, Stough WG, Gheorghiade M, Greenberg BH, et al. Carvedilol use at discharge in patients hospitalized for heart failure is associated with improved survival: an analysis from Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failure (OPTIMIZE-HF). Am Heart J. 2007;153:82e1–11
  14. Gabow P, Eisert S, Wright R. Denver Health: a model for the integration of a public hospital and community health centers. Ann Intern Med. 2003;138:143–149
  15. Lucas DL, Brown RA, Wassef M, Giles TD. Alcohol and the cardiovascular system. J Am Coll Cardiol. 2005;45:1916–1924
  16. Lange RA, Hillis LD. Cardiovascular complications of cocaine use. N Engl J Med. 2001;345:351–358
  17. Schiller NB, Shah PM, Crawford M, DeMaria A, Devereux R, Feigenbaum H, et al. American Society of Echocardiography Committee on Standards on Quantification of Two-Dimensional Echocardiograms: recommendations for quantitation of the left ventricle by two-dimensional echocardiography. J Am Soc Echo. 1989;2:358–367
  18. Krum H, Roecker EB, Mohacsi P, Rouleau JL, Tendera M, Coats AJ, et al. Effects of initiating carvedilol in patients with severe chronic heart failure: results from the COPERNICUS study. JAMA. 2003;289:712–718
  19. DeBusk RB, Miller NH, Parker KM, Bandura A, Kraemer HC, Cher DJ, et al. Care management for low-risk patients with heart failure: a randomized, controlled trial. Ann Intern Med. 2004;141:606–613
  20. Sisk JE, Hebert PL, Horowitz CR, McLaughlin MA, Wang JJ, Chassin MR. Effects of nurse management on the quality of heart failure care in minority communities: a randomized trial. Ann Intern Med. 2006;145:273–283
  21. Willenheimer R, van Veldhuisen DJ, Silke B, Erdmann E, Follath F, Krum H, et al. Effect on survival and hospitalization of initiating treatment for chronic heart failure with bisoprolol followed by enalapril, as compared with the opposite sequence: results of the randomized Cardiac Insufficiency Bisoprolol Study (CIBIS) III. Circulation. 2005;112:2426–2435
  22. Butler J, Young JB, Abraham WT, Bourge RC, Adams KF, Clare R, et al. Beta-blocker use and outcomes among hospitalized heart failure patients. J Am Coll Cardiol. 2006;47:2462–2469
  23. Fonarow GC, Abraham WT, Albert NM, Stough WG, Gheorghiade M, Greenberg BH, et al. Association between performance measures and clinical outcomes for patients hospitalized with heart failure. JAMA. 2007;297:61–70
  24. Gilbert EM, Abraham WT, Olsen S, Hattler B, White M, Mealy P, et al. Comparative hemodynamic, left ventricular functional, and antiadrenergic effects of chronic treatment with metoprolol versus carvedilol in the failing heart. Circulation. 1996;94:2817–2825
  25. Race and the response to adrenergic blockade with carvedilol in patients with chronic heart failure. N Engl J Med. 2001;344:1358–1365
  26. Labresh KA, Ellrodt GE, Gliklich R, Liljestrand J, Peto R. Get with the guidelines for cardiovascular secondary prevention: pilot results. Arch Int Med. 2004;203–209
  27. Jessup M, Brozena S. Medical progress: heart failure. N Engl J Med. 2003;348:2007–2018
  28. Roumie CL, Elasy TA, Greevy R, Griffin MR, Liu X, Stone WJ, et al. Improving blood pressure control through provider education, provider alerts, and patient education: a cluster randomized trial. Ann Intern Med. 2006;145:165–175
  29. Pitt B, Zannad F, Remme WJ, Cody R, Castaigne A, Perez A, et al The effect of spironolactone on morbidity and mortality in patients with severe heart failure. N Engl J Med. 1999;341:709–717

 MK and CSL report having received consulting fees from GlaxoSmithKline and AstraZeneca.

 The trial was an investigator initiated study funded by Glaxo Smith Kline; Philadelphia, PA. The sponsor had no role in the conception, design, or implementation of the trial. Interpretation and analysis of all data were done solely by the clinical investigators. Clinicaltrials.gov identifier: NCT00381030.

PII: S1071-9164(07)01167-0

doi: 10.1016/j.cardfail.2007.12.008

Journal of Cardiac Failure
Volume 14, Issue 4 , Pages 303-309 , May 2008

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